microRNA sequencing report

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1. Introduction

microRNA (abbreviated miRNA) is small non-coding RNA molecules (containing about 22 nucleotides) found in plants, animals and some viruses, which functions in RNA silencing and post-transcriptional regulation of gene expression. While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media.

Encoded by eukaryotic nuclear DNA in plants and animals and by viral DNA in certain viruses whose genome is based on DNA, miRNAs function via base-pairing with complementary sequences within mRNA molecules. As a result, these mRNA molecules are silenced, by one or more of the following processes: (a) cleavage of the mRNA strand into two pieces, (b) destabilization of the mRNA through shortening of its poly(A) tail, and (c) less efficient translation of the mRNA into proteins by ribosomes.

Generation of miRNAs in animals and plants

miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals

miRNAs are well conserved in both plants and animals, and are thought to be a vital and evolutionarily ancient component of gene regulation. While core components of the microRNA pathway are conserved between plants and animals, miRNA repertoires in the two kingdoms appear to have emerged independently with different primary modes of action.

Plant miRNAs usually have near-perfect pairing with their mRNA targets, which induces gene repression through cleavage of the target transcripts. In contrast, animal miRNAs are able to recognize their target mRNAs by using as little as 6–8 nucleotides (the seed region) at the 5' end of the miRNA, which is not enough pairing to induce cleavage of the target mRNAs. Combinatorial regulation is a feature of miRNA regulation in animals. A given miRNA may have hundreds of different mRNA targets, and a given target might be regulated by multiple miRNAs.

The first miRNA was discovered in the early 1990s. However, miRNAs were not recognized as a distinct class of biological regulators until the early 2000s. miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. Aberrant miRNA expression are implicated in disease states. MiRNA-based therapies are under investigation.

Target gene inhibited by miRNAs in animal and plant

Estimates of the average number of unique messenger RNAs that are targets for repression by a typical miRNA vary, depending on the estimation method, but multiple approaches show that mammalian miRNAs can have many unique targets. For example, an analysis of the miRNAs highly conserved in vertebrates shows that each has, on average, roughly 400 conserved targets. Likewise, experiments show that a single miRNA species can reduce the stability of hundreds of unique messenger RNAs. Other experiments show that a single miRNA species may repress the production of hundreds of proteins, but that this repression often is relatively mild (much less than 2-fold). The first human disease associated with deregulation of miRNAs was chronic lymphocytic leukemia. Other B cell malignancies followed.

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2. Materials and Methods

2.1 Library construction and sequencing

Total RNA was extracted using Trizol reagent (Invitrogen, CA, USA) following the manufacturer's procedure. The total RNA quality and quantity were analysis of Bioanalyzer 2100 (Agilent, CA, USA) with RIN number >7.0. Approximately 1 ug of total RNA were used to prepare small RNA library according to protocol of TruSeq Small RNA Sample Prep Kits(Illumina, San Diego, USA). And then we performed the single-end sequencing 50bp on an Illumina Hiseq 4000 at LC Sciences following the vendor's recommended protocol.

Workflow of library construction

2.2 Bioinformatics analysis

Animal: Raw reads were subjected to an in-house program, ACGT101-miR (LC Sciences, Houston, Texas, USA) to remove adapter dimers, junk, low complexity, common RNA families (rRNA, tRNA, snRNA, snoRNA) and repeats. Subsequently, unique sequences with length in 18~26 nucleotide were mapped to specific species precursors in miRBase 21.0 by BLAST search to identify known miRNAs and novel 3p- and 5p- derived miRNAs. Length variation at both 3’ and 5’ ends and one mismatch inside of the sequence were allowed in the alignment. The unique sequences mapping to specific species mature miRNAs in hairpin arms were identified as known miRNAs. The unique sequences mapping to the other arm of known specific species precursor hairpin opposite to the annotated mature miRNA-containing arm were considered to be novel 5p- or 3p derived miRNA candidates. The remaining sequences were mapped to other selected species precursors (with the exclusion of specific species) in miRBase 21.0 by BLAST search, and the mapped pre-miRNAs were further BLASTed against the specific species genomes to determine their genomic locations. The above two we defined as known miRNAs. The unmapped sequences were BLASTed against the specific genomes, and the hairpin RNA structures containing sequences were predicated from the flank 80 nt sequences using RNAfold software (http://rna.tbi.univie.ac.at/cgi-bin/RNAWebSuite/RNAfold.cgi). The criteria for secondary structure prediction were: (1) number of nucleotides in one bulge in stem (≤12) (2) number of base pairs in the stem region of the predicted hairpin (≥16) (3) cutoff of free energy (kCal/mol ≤-15) (4) length of hairpin (up and down stems + terminal loop ≥50) (5) length of hairpin loop (≤20). (6) number of nucleotides in one bulge in mature region (≤8) (7) number of biased errors in one bulge in mature region (≤4) (8) number of biased bulges in mature region (≤2) (9) number of errors in mature region (≤7) (10) number of base pairs in the mature region of the predicted hairpin (≥12) (11) percent of mature in stem (≥80).

Plant: Raw reads were subjected to an in-house program, ACGT101-miR (LC Sciences, Houston, Texas, USA) to remove adapter dimers, junk, low complexity, common RNA families (rRNA, tRNA, snRNA, snoRNA) and repeats. Subsequently, unique sequences with length in 18~25 nucleotide were mapped to specific species precursors in miRBase 21.0 by BLAST search to identify known miRNAs and novel 3p- and 5p- derived miRNAs. Length variation at both 3’ and 5’ ends and one mismatch inside of the sequence were allowed in the alignment. The unique sequences mapping to specific species mature miRNAs in hairpin arms were identified as known miRNAs. The unique sequences mapping to the other arm of known specific species precursor hairpin opposite to the annotated mature miRNA-containing arm were considered to be novel 5p- or 3p derived miRNA candidates. The remaining sequences were mapped to other selected species precursors (with the exclusion of specific species) in miRBase 21.0 by BLAST search, and the mapped pre-miRNAs were further BLASTed against the specific species genomes to determine their genomic locations. The above two we defined as known miRNAs. The unmapped sequences were BLASTed against the specific genomes, and the hairpin RNA structures containing sequences were predicated from the flank 120 nt sequences using RNAfold software (http://rna.tbi.univie.ac.at/cgi-bin/RNAWebSuite/RNAfold.cgi). The criteria for secondary structure prediction were: (1) number of nucleotides in one bulge in stem (≤12) (2) number of base pairs in the stem region of the predicted hairpin (≥16) (3) cutoff of free energy (kCal/mol ≤-15) (4) length of hairpin (up and down stems + terminal loop ≥50) (5) length of hairpin loop (≤200). (6) number of nucleotides in one bulge in mature region (≤4) (7) number of biased errors in one bulge in mature region (≤2) (8) number of biased bulges in mature region (≤2) (9) number of errors in mature region (≤4) (10) number of base pairs in the mature region of the predicted hairpin (≥12) (11) percent of mature in stem (≥80).

Bioinformatics pipeline for miRNA

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3. Project information

3.1 Sample information

Species name: Mice

Latin name: Mus musculus

Specimens: tissue

3.2 Compare groups

Sample Name	Sample Species	Biological Replicates
C_3MK5	Mus_musculus	C_3MK
C_3MK6	Mus_musculus	C_3MK
C_3MK7	Mus_musculus	C_3MK
C_3MK8	Mus_musculus	C_3MK
C_3MK9	Mus_musculus	C_3MK
C_12MK17	Mus_musculus	C_12MK
C_12MK18	Mus_musculus	C_12MK
C_12MK19	Mus_musculus	C_12MK
C_12MK20	Mus_musculus	C_12MK
C_12MK21	Mus_musculus	C_12MK
C_24MK31	Mus_musculus	C_24MK
C_24MK32	Mus_musculus	C_24MK
C_24MK33	Mus_musculus	C_24MK
C_24MK34	Mus_musculus	C_24MK
C_24MK35	Mus_musculus	C_24MK

3.3 Database

Dababase	Web links	Version/date
miRNA/Pre-miRNA database (miRbase)	ftp://miRbase.org/pub/miRbase/CURRENT	21.0
Rfam	http://rfam.janelia.org	13.0
Repbase	http://www.girinst.org/repbase	2017.09
Genome	ftp://ftp.sanger.ac.uk/pub/gencode/Gencode_mouse/release_M16/GRCm38.p5.genome.fa.gz	GRCm38.p5
Gene Ontology (GO)	ftp://ftp.ncbi.nih.gov/gene/DATA/gene2go.gz	2016.04
KEGG	http://www.genome.jp/kegg/pathway.html	2017.06
eggNOG	http://eggnogdb.embl.de/	4.5

3.4 Bioinformatics software

Small RNA sequencing data were analyzed by in-house program ACGT101-miR. More details were mentioned in 2.2 Bioinformatics analysis.

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4. Results

4.1 Overview of read characteristics by library

We assessed the general characteristics of the reads obtained for the different libraries. 3' adapter sequence must be removed prior to further processing of the data. After adapter removal, the length distribution of of the trimmed reads should correspond to the length distribution of the RNAs sequenced as showed in 4.1.3 Length distribution of sRNA below. Only the 18–30 nt size range is shown as this was the input for sequencing. 4.1.1 Overview of reads from rawdata to cleandata shows valid reads by removing mRNA, junk reads and other kinds of reads from Rfam (rRNA, snoRNA, tRNA, etc.). 4.1.2 Rfam category shows distribution of different RNA class in small RNA sequencing data. What's more, results of FastQC, PCA analysis and sample correlation were deposited in Final_Report/3_Summary/0_Quality_Control.

4.1.1 Overview of reads from rawdata to cleandata

Raw data were filtered using a filter module in a in-house program ACGT101-miR to delete low-quality reads, 3' adapter sequences, and contaminations. The sequences ≥18 nt of clean data were annotated in the Rfam database (http://www.sanger.ac.uk/software/Rfam) to remove non-coding RNA (rRNA, tRNA, snRNA, snoRNA) and degradation fragments of mRNA. The remaining sequences were aligned against miRNA database, miRbase (Release 21) (http://www.miRbase.org/) and perfectly matched sequences were considered conserved Mus musculus miRNAs.

		C_3MK5				C_3MK6				C_3MK7				C_3MK8				C_3MK9				C_12MK17				C_12MK18				C_12MK19				C_12MK20				C_12MK21				C_24MK31				C_24MK32				C_24MK33				C_24MK34				C_24MK35
lib	type	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq	Total	% of Total	uniq	% of uniq
Raw reads	NA	14578293	100.00	576510	100.00	16475059	100.00	659931	100.00	20661946	100.00	721667	100.00	14371816	100.00	551980	100.00	17274337	100.00	575333	100.00	14982298	100.00	608337	100.00	15652841	100.00	600300	100.00	18987387	100.00	631713	100.00	14756089	100.00	591895	100.00	17586591	100.00	761879	100.00	18557746	100.00	656899	100.00	17156205	100.00	687680	100.00	13967605	100.00	551509	100.00	22929871	100.00	718885	100.00	20149042	100.00	713151	100.00
3ADT&length filter	Sequence type	1011547	6.94	356114	61.77	2260620	13.72	413841	62.71	1875844	9.08	463273	64.19	1300625	9.05	329329	59.66	1210763	7.01	361570	62.85	1308692	8.73	380545	62.55	1331444	8.51	382671	63.75	1174141	6.18	417841	66.14	1043984	7.07	396522	66.99	1449497	8.24	516492	67.79	996709	5.37	431170	65.64	1416714	8.26	445087	64.72	1112985	7.97	373853	67.79	1133993	4.95	494116	68.73	1164898	5.78	453817	63.64
Junk reads	Sequence type	34440	0.24	5077	0.88	33953	0.21	5331	0.81	24302	0.12	5117	0.71	26229	0.18	5184	0.94	22454	0.13	4770	0.83	19108	0.13	4648	0.76	23207	0.15	5552	0.92	22850	0.12	5181	0.82	15445	0.10	3975	0.67	23578	0.13	5801	0.76	19367	0.10	4826	0.73	22048	0.13	5294	0.77	15280	0.11	3800	0.69	31037	0.14	5994	0.83	20511	0.10	5027	0.70
Rfam	RNA class	107469	0.74	3129	0.54	142996	0.87	4643	0.70	204054	0.99	4080	0.57	114788	0.80	3079	0.56	145336	0.84	3013	0.52	135199	0.90	3359	0.55	148957	0.95	3191	0.53	161411	0.85	3274	0.52	143415	0.97	2943	0.50	138743	0.79	3868	0.51	128207	0.69	2881	0.44	172248	1.00	3769	0.55	89783	0.64	2310	0.42	143531	0.63	3223	0.45	154913	0.77	3194	0.45
mRNA	RNA class	1591468	10.92	3071	0.53	1944487	11.80	4110	0.62	2438063	11.80	3649	0.51	1592887	11.08	3086	0.56	2012822	11.65	2927	0.51	2022122	13.50	3183	0.52	2077423	13.27	3167	0.53	2455139	12.93	3185	0.50	1849089	12.53	2771	0.47	2119225	12.05	3570	0.47	2211237	11.92	3011	0.46	2082548	12.14	3396	0.49	1591303	11.39	2399	0.43	2639378	11.51	3200	0.45	2401162	11.92	3172	0.44
Repeats	RNA class	18937	0.13	470	0.08	23945	0.15	686	0.10	37860	0.18	626	0.09	23742	0.17	512	0.09	29629	0.17	505	0.09	32262	0.22	532	0.09	28183	0.18	538	0.09	31230	0.16	548	0.09	30462	0.21	517	0.09	25085	0.14	625	0.08	28087	0.15	495	0.08	36605	0.21	608	0.09	20049	0.14	418	0.08	24892	0.11	529	0.07	40389	0.20	561	0.08
valid reads	Sequence type	11855131	81.32	209541	36.35	12129977	73.63	232725	35.27	16148758	78.16	246063	34.10	11357361	79.03	211712	38.36	13899738	80.46	203412	35.36	11518353	76.88	217029	35.68	12092689	77.26	206137	34.34	15192912	80.02	202645	32.08	11722455	79.44	186044	31.43	13883043	78.94	232665	30.54	15216449	82.00	215355	32.78	13490486	78.63	230624	33.54	11169025	79.96	169416	30.72	18999435	82.86	212741	29.59	16424432	81.51	248340	34.82

rRNA	RNA class	39332	0.27	925	0.01	67915	0.41	2037	0.01	55011	0.27	1072	0.01	36523	0.25	916	0.01	33278	0.19	517	0.00	38077	0.25	938	0.01	39807	0.25	794	0.01	35439	0.19	663	0.00	33637	0.23	593	0.00	54595	0.31	1365	0.01	34169	0.18	520	0.00	48385	0.28	1043	0.01	26909	0.19	394	0.00	40213	0.18	599	0.00	39036	0.19	585	0.00
tRNA	RNA class	40691	0.28	1278	0.01	40215	0.24	1249	0.01	107349	0.52	1768	0.01	49256	0.34	1211	0.01	78001	0.45	1519	0.01	65726	0.44	1376	0.01	76949	0.49	1388	0.01	88102	0.46	1527	0.01	79992	0.54	1431	0.01	46106	0.26	1248	0.01	58725	0.32	1342	0.01	86264	0.50	1529	0.01	36504	0.26	1088	0.01	59348	0.26	1445	0.01	75296	0.37	1500	0.01
snoRNA	RNA class	21587	0.15	646	0.00	25141	0.15	798	0.00	33196	0.16	874	0.00	22301	0.16	671	0.00	28106	0.16	784	0.00	23894	0.16	735	0.00	25498	0.16	740	0.00	31054	0.16	837	0.00	23951	0.16	704	0.00	29416	0.17	842	0.00	29365	0.16	790	0.00	28673	0.17	836	0.00	21527	0.15	657	0.00	36529	0.16	924	0.00	32484	0.16	861	0.00
snRNA	RNA class	2991	0.02	63	0.00	4415	0.03	97	0.00	3565	0.02	83	0.00	3292	0.02	54	0.00	2571	0.01	61	0.00	3544	0.02	66	0.00	2820	0.02	58	0.00	2917	0.02	70	0.00	2527	0.02	58	0.00	3881	0.02	77	0.00	2562	0.01	63	0.00	3981	0.02	87	0.00	2238	0.02	57	0.00	3157	0.01	67	0.00	3276	0.02	74	0.00
other Rfam RNA	RNA class	2868	0.02	217	0.00	5310	0.03	462	0.00	4933	0.02	283	0.00	3416	0.02	227	0.00	3380	0.02	132	0.00	3958	0.03	244	0.00	3883	0.02	211	0.00	3899	0.02	177	0.00	3308	0.02	157	0.00	4745	0.03	336	0.00	3386	0.02	166	0.00	4945	0.03	274	0.00	2605	0.02	114	0.00	4284	0.02	188	0.00	4821	0.02	174	0.00

document location: Final_Report/3_Summary/1_SequencingData_Overview/Table2_Overview_of_reads_from_raw_data_to_cleaned_sequences.xlsx

4.1.2 Rfam category

document location: Final_Report/3_Summary/1_SequencingData_Overview/Fig1_Rfam_sequence_category.pdf

4.1.3 Length distribution of sRNA

document location:

Final_Report/3_Summary/1_SequencingData_Overview/Fig3_Length_distribution_of_counts_of_total_and_unique_sRNAs_in_this_study.pdf

Final_Report/3_Summary/1_SequencingData_Overview/Table4_The_length_and_counts_characteristics_of_the_sequencing_results.xlsx

4.2 Identification of conserved and novel miRNA

After processed by filter module in ACGT101-miR, unique reads were analyzed using ACGT101-miR to detect conserved and novel Mus musculus miRNAs. Briefly, those unique reads which were mapped to miRNAs/pre-miRNAs of specific species in miRbase and the pre-miRNAs were further mapped to genome & EST were belonged to gp1a. In gp1b, reads were mapped to (except for specific species) miRNAs/pre-miRNAs of selected species in miRbase and the pre-miRNAs were further mapped to genome & EST. Reads from gp2a were mapped to miRNAs/pre-miRNAs of selected species in miRbase and the mapped pre-miRNAs were not further mapped to genome, but the reads (and of course the miRNAs of the pre-miRNAs) were mapped to genome. The extended genome sequences from the genome loci may form hairpins. In gp2b, Reads were mapped to miRNAs/pre-miRNAs of selected species in miRbase and the mapped pre-miRNAs were not further mapped to genome, but the reads (and of course the miRNAs of the pre-miRNAs) were mapped to genome. The extended genome sequences from the genome loci may not form hairpins. Those reads which were mapped to miRNAs/pre-miRNAs of selected species in miRbase and the mapped pre-miRNAs were not further mapped to genome, and the reads were not mapped to genome, either, but the reads were mapped to the miRNAS(Matures), were classified as gp3. Reads in gp4 were not mapped to pre-miRNAs of selected species in miRbase. But the reads were mapped to genome & the extended genome sequences from genome may form hairpins. More details and informations are listed in Table5_All_Expressed_miRNA.xlsx.

Normalization of sequence counts in each sample (or data set) is achieved by dividing the counts by a library size parameter of the corresponding sample. The library size parameter is a median value of the ratio between the counts a specific sample and a pseudo-reference sample. A count number in the pseudo-reference sample is the count geometric mean across all samples.

, where Sj is the library size parameter; cij is the count number of sequence i of sample j; m is the total number of samples involved.

Pre-miRNA Index	miRNA_Index	miR_name	miR_seq	len	genomeID	strand	start	end	pre-miRNA_seq	#mir/MIR	mirIDs,	rep_mirID	rep_mirSeq	rep_miRID	rep_miRSeq	type	Sequence in miRbase	group	SS	hairpinLen	CG%	dG	C_3MK5(raw)	C_3MK6(raw)	C_3MK7(raw)	C_3MK8(raw)	C_3MK9(raw)	C_12MK17(raw)	C_12MK18(raw)	C_12MK19(raw)	C_12MK20(raw)	C_12MK21(raw)	C_24MK31(raw)	C_24MK32(raw)	C_24MK33(raw)	C_24MK34(raw)	C_24MK35(raw)	C_3MK5(norm)	C_3MK6(norm)	C_3MK7(norm)	C_3MK8(norm)	C_3MK9(norm)	C_12MK17(norm)	C_12MK18(norm)	C_12MK19(norm)	C_12MK20(norm)	C_12MK21(norm)	C_24MK31(norm)	C_24MK32(norm)	C_24MK33(norm)	C_24MK34(norm)	C_24MK35(norm)	Expression level
1	1	mmu-miR-1a-3p	TGGAATGTAAAGAAGTATGTAT	22	chr18	-	10785474	10785557	cctactcagagcacatacttctttatgtacccatatgaacattcagtgctaTGGAATGTAAAGAAGTATGTATtttgggtaggt	12	mmu-mir-1a-2,hsa-mir-1-2,bta-mir-1-2,ppa-mir-1,eca-mir-1-1,ptr-mir-1-2,mml-mir-1-2,cfa-mir-1-2,efu-mir-1-1,mdo-mir-1-1,gga-mir-1a-2,tgu-mir-1-2,	mmu-mir-1a-2	tcagagcACATACTTCTTTATGTACCCATAtgaacattcagtgctaTGGAATGTAAAGAAGTATGTATtttg	mmu-miR-1a-3p	TGGAATGTAAAGAAGTATGTAT	3'	Yes	gp1a	((((((((((..(((((((((((((..(..(((((...((.....))..))))).)..)))))))))))))..)))))))))).	83	36.90	-37.70	1510	858.50	946	1059	1490	923.50	754	1171	884	925	1135.50	918	754.50	1326	1010	1781.71	972.94	764.63	1334.57	1422.63	1030.76	827.80	1017.99	997.51	888.39	1021.64	904.85	916.05	965.67	836.43	middle
2	2	mmu-miR-1a-3p	TGGAATGTAAAGAAGTATGTAT	22	chr2	+	180389043	180389135	tacctgcttgggacacatacttctttatatgcccatatgaacctgctaagctaTGGAATGTAAAGAAGTATGTATttcaggctaggaactctc	15	mmu-mir-1a-1,rno-mir-1b,hsa-mir-1-1,ppy-mir-1-1,bta-mir-1-1,eca-mir-1-2,ptr-mir-1-1,mml-mir-1-1,cfa-mir-1-1,mdo-mir-1-2,ssc-mir-1,chi-mir-1,gga-mir-1a-1,tgu-mir-1-1,xtr-mir-1a-2,	mmu-mir-1a-1	gcttgggacACATACTTCTTTATATGCCCATAtgaacctgctaagctaTGGAATGTAAAGAAGTATGTATttcaggc	mmu-miR-1a-3p	TGGAATGTAAAGAAGTATGTAT	3'	Yes	gp1a	..((((((((..(.((((((((((((((((..(((((..............))))).)))))))))))))))).)..))))).))).......	84	39.80	-37.60	1510	858.50	946	1059	1490	923.50	754	1171	884	925	1135.50	918	754.50	1326	1010	1781.71	972.94	764.63	1334.57	1422.63	1030.76	827.80	1017.99	997.51	888.39	1021.64	904.85	916.05	965.67	836.43	middle
3	3	mmu-miR-1b-3p	TGGGTACATAAAGAAGTATGTGC	23	chr18	+	10785446	10785567	ttcctttagcttcttcttggcggacattacctacccaaaatacatacttctttacattccatagcactgaatgttcataTGGGTACATAAAGAAGTATGTGCtctgagtaggcactcctgcg	2	mmu-mir-1b,rno-mir-3571,	mmu-mir-1b	ttcctttagcttcttcttggcggacattacctacccaaaaTACATACTTCTTTACATTCCAtagcactgaatgttcataTGGGTACATAAAGAAGTATGTGCtctgagtaggcactcctgcg	mmu-miR-1b-3p	TGGGTACATAAAGAAGTATGTGC	3'	Yes	gp1a	...................((((......(((((.((...((((((((((((((...((((((..((.....))...))))))....))))))))))))))...)).))))).....)))).	102	41	-35.20	0	5	0	0	6	0	0	6	0	8	0	0	0	8	0	0	5.67	0	0	5.73	0	0	5.22	0	7.68	0	0	0	5.83	0	low
4	4	mmu-let-7d-5p	AGAGGTAGTAGGTTGCATAGTT	22	chr13	-	48536010	48536115	aaatgggttcctaggaAGAGGTAGTAGGTTGCATAGTTttagggcagagattttgcccacaaggagttaaCTATACGACCTGCTGCCTTTCTtagggccttattat	16	mmu-let-7d,rno-let-7d,cgr-let-7d,hsa-let-7d,ppy-let-7d,mml-let-7d,oar-let-7d,bta-let-7d,eca-let-7d,ptr-let-7d,cfa-let-7d,mdo-let-7d,oan-let-7d,ssc-let-7d,chi-let-7d,tgu-let-7d,	mmu-let-7d	aatgggttcctaggaAGAGGTAGTAGGTTGCATAGTTttagggcagagattttgcccacaaggagttaaCTATACGACCTGCTGCCTTTCTtagggccttatt	mmu-let-7d-5p	AGAGGTAGTAGGTTGCATAGTT	5'	Yes	gp1a	.(((..(..((((((.(((((((((((((((.((((((...(((((((...)))))))..........)))))).)))))))))))))))))))))..)..)))..	103	43.40	-49.40	87430.75	95932.75	124162.75	82723.50	95685	88941.25	83448.50	115566.45	83961.25	95370	109253.90	103739.20	74165.30	125374.50	111162.75	103163.28	108720.56	100357.35	104249.94	91358.73	99271.49	91616.53	100465.66	94742.35	91595.72	98298.29	102252.88	90044.83	91304.64	92059.33	high
4	5	mmu-let-7d-3p	CTATACGACCTGCTGCCTTTCT	22	chr13	-	48536010	48536115	aaatgggttcctaggaAGAGGTAGTAGGTTGCATAGTTttagggcagagattttgcccacaaggagttaaCTATACGACCTGCTGCCTTTCTtagggccttattat	16	mmu-let-7d,rno-let-7d,cgr-let-7d,hsa-let-7d,ppy-let-7d,mml-let-7d,oar-let-7d,bta-let-7d,eca-let-7d,ptr-let-7d,cfa-let-7d,mdo-let-7d,oan-let-7d,ssc-let-7d,chi-let-7d,tgu-let-7d,	mmu-let-7d	aatgggttcctaggaAGAGGTAGTAGGTTGCATAGTTttagggcagagattttgcccacaaggagttaaCTATACGACCTGCTGCCTTTCTtagggccttatt	mmu-let-7d-3p	CTATACGACCTGCTGCCTTTCT	3'	Yes	gp1a	.(((..(..((((((.(((((((((((((((.((((((...(((((((...)))))))..........)))))).)))))))))))))))))))))..)..)))..	103	43.40	-49.40	5892	6692	9600	5466	6539	6036	6448	7021	5111	7416	7361	7955	5064	7453	6617	6952.22	7584.04	7759.42	6888.37	6243.35	6737.06	7079.14	6103.58	5767.28	7122.51	6622.86	7841.02	6148.25	5427.69	5479.86	middle
5	6	mmu-let-7i-5p	TGAGGTAGTAGTTTGTGCTGTT	22	chr10	-	122985632	122985735	acaccatggccctggcTGAGGTAGTAGTTTGTGCTGTTggtcgggttgtgacattgcccgctgtggagataaCTGCGCAAGCTACTGCCTTGCTagtgctggtg	18	mmu-let-7i,rno-let-7i,mml-let-7i,ssc-let-7i,aja-let-7i,cgr-let-7i,hsa-let-7i,bta-let-7i,ppy-let-7i,mdo-let-7i,oar-let-7i,gga-let-7i,ptr-let-7i,ggo-let-7i,chi-let-7i,tch-let-7i,tgu-let-7i,xtr-let-7i,	mmu-let-7i	ctggcTGAGGTAGTAGTTTGTGCTGTTggtcgggttgtgacattgcccgctgtggagataaCTGCGCAAGCTACTGCCTTGCTag	mmu-let-7i-5p	TGAGGTAGTAGTTTGTGCTGTT	5'	Yes	gp1a	.((((..(((.(((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))).)))))))	103	55.80	-51.90	63879	56933	90960	55062	76767.50	67125.50	73201.50	87144	59565	66241	79112.50	73630	54588	91369.50	88415.50	75373.56	64522.15	73520.48	69390.32	73296.56	74921.91	80366.54	75757.11	67213.48	63619.51	71179.37	72575.07	66275.84	66540.32	73221.21	high
5	7	mmu-let-7i-3p	CTGCGCAAGCTACTGCCTTGCT	22	chr10	-	122985632	122985735	acaccatggccctggcTGAGGTAGTAGTTTGTGCTGTTggtcgggttgtgacattgcccgctgtggagataaCTGCGCAAGCTACTGCCTTGCTagtgctggtg	18	mmu-let-7i,rno-let-7i,mml-let-7i,ssc-let-7i,aja-let-7i,cgr-let-7i,hsa-let-7i,bta-let-7i,ppy-let-7i,mdo-let-7i,oar-let-7i,gga-let-7i,ptr-let-7i,ggo-let-7i,chi-let-7i,tch-let-7i,tgu-let-7i,xtr-let-7i,	mmu-let-7i	ctggcTGAGGTAGTAGTTTGTGCTGTTggtcgggttgtgacattgcccgctgtggagataaCTGCGCAAGCTACTGCCTTGCTag	mmu-let-7i-3p	CTGCGCAAGCTACTGCCTTGCT	3'	Yes	gp1a	.((((..(((.(((((.(((((((((((((((((.(((((.(((((.........)))))))........))).)))))))))))))))))))))).)))))))	103	55.80	-51.90	672	690	1117	583	895	815	715	998	755	785	822	752	708	1146	1051	792.92	781.98	902.84	734.71	854.53	909.66	784.98	867.59	851.95	753.93	739.57	741.23	859.59	834.58	870.38	middle
6	8	mmu-let-7b-5p	TGAGGTAGTAGGTTGTGTGGTT	22	chr15	+	85707316	85707415	accgcagggTGAGGTAGTAGGTTGTGTGGTTtcagggcagtgatgttgcccctccgaagataaCTATACAACCTACTGCCTTCCCtgaggcgcccaggga	16	mmu-let-7b,rno-let-7b,cgr-let-7b,hsa-let-7b,bta-let-7b,ppy-let-7b,mml-let-7b,ptr-let-7b,cfa-let-7b,mdo-let-7b,oan-let-7b,ggo-let-7b,chi-let-7b,oar-let-7b,gga-let-7b,tgu-let-7b,	mmu-let-7b	gcagggTGAGGTAGTAGGTTGTGTGGTTtcagggcagtgatgttgcccctccgaagataaCTATACAACCTACTGCCTTCCCtga	mmu-let-7b-5p	TGAGGTAGTAGGTTGTGTGGTT	5'	Yes	gp1a	.((.(((((.(((((((((((((((((((((((.((((((.....))))))....))....)))))))))))))))))))))))))).))..........	89	56	-52.20	124074.17	111457.67	173696.17	101741.83	121245.25	114322.42	118948.75	146691.75	113715.50	137365.42	151068	153744.08	109373.75	181118.42	168965.33	146400.41	126314.94	140393.86	128217.25	115763.31	127600.59	130591.58	127523.90	128317.21	131929.17	135919.42	151541.31	132791.76	131900.45	139928.48	high
6	9	mmu-let-7b-3p_1ss22CT	CTATACAACCTACTGCCTTCCT	22	chr15	+	85707316	85707415	accgcagggTGAGGTAGTAGGTTGTGTGGTTtcagggcagtgatgttgcccctccgaagataaCTATACAACCTACTGCCTTCCCtgaggcgcccaggga	16	mmu-let-7b,rno-let-7b,cgr-let-7b,hsa-let-7b,bta-let-7b,ppy-let-7b,mml-let-7b,ptr-let-7b,cfa-let-7b,mdo-let-7b,oan-let-7b,ggo-let-7b,chi-let-7b,oar-let-7b,gga-let-7b,tgu-let-7b,	mmu-let-7b	gcagggTGAGGTAGTAGGTTGTGTGGTTtcagggcagtgatgttgcccctccgaagataaCTATACAACCTACTGCCTTCCCtga	mmu-let-7b-3p	CTATACAACCTACTGCCTTCCC	3'	Diff	gp1a	.((.(((((.(((((((((((((((((((((((.((((((.....))))))....))....)))))))))))))))))))))))))).))..........	89	56	-52.20	1238	1215	1802	1055	1335	1095	1283	1431	1023	1397	1513	1465	1100	1704	1683	1460.77	1376.96	1456.51	1329.53	1274.64	1222.18	1408.58	1244.01	1154.36	1341.71	1361.28	1444.01	1335.52	1240.95	1393.77	middle
7	10	mmu-let-7e-5p	TGAGGTAGGAGGTTGTATAGTT	22	chr17	+	17830346	17830450	acctgccgcgccccccgggcTGAGGTAGGAGGTTGTATAGTTgaggaagacacccgaggagatcaCTATACGGCCTCCTAGCTTTCCccaggctgcgccctgcac	13	mmu-let-7e,rno-let-7e,hsa-let-7e,bta-let-7e,ppy-let-7e,mml-let-7e,eca-let-7e,ptr-let-7e,cfa-let-7e,ssc-let-7e,ggo-let-7e,chi-let-7e,tch-let-7e,	mmu-let-7e	cgcgccccccgggcTGAGGTAGGAGGTTGTATAGTTgaggaagacacccgaggagatcaCTATACGGCCTCCTAGCTTTCCccaggctgcgcc	mmu-let-7e-5p	TGAGGTAGGAGGTTGTATAGTT	5'	Yes	gp1a	...(((.((((..((.(((..(((.(((((((..(((((((.((..................)))))))))..))))))).)))..))).))..))))...))).	101	62.90	-46.30	21220.17	20859.92	31673.42	18465.17	24169.92	20610.83	21243.67	27824.25	20395	22601.33	26003.83	25761.67	18812.50	31521	31626.58	25038.58	23640.54	25600.76	23270.20	23077.11	23004.71	23323.02	24188.52	23013.83	21706.88	23396.26	25392.57	22840.44	22955.34	26191.52	high
7	11	mmu-let-7e-3p	CTATACGGCCTCCTAGCTTTCC	22	chr17	+	17830346	17830450	acctgccgcgccccccgggcTGAGGTAGGAGGTTGTATAGTTgaggaagacacccgaggagatcaCTATACGGCCTCCTAGCTTTCCccaggctgcgccctgcac	13	mmu-let-7e,rno-let-7e,hsa-let-7e,bta-let-7e,ppy-let-7e,mml-let-7e,eca-let-7e,ptr-let-7e,cfa-let-7e,ssc-let-7e,ggo-let-7e,chi-let-7e,tch-let-7e,	mmu-let-7e	cgcgccccccgggcTGAGGTAGGAGGTTGTATAGTTgaggaagacacccgaggagatcaCTATACGGCCTCCTAGCTTTCCccaggctgcgcc	mmu-let-7e-3p	CTATACGGCCTCCTAGCTTTCC	3'	Yes	gp1a	...(((.((((..((.(((..(((.(((((((..(((((((.((..................)))))))))..))))))).)))..))).))..))))...))).	101	62.90	-46.30	324	352	641	334	480	381	384	468	353	406	473	399	370	574	497	382.30	398.92	518.10	420.91	458.30	425.25	421.59	406.85	398.33	389.93	425.57	393.28	449.22	418.02	411.59	middle
8	12	mmu-miR-7b-5p	TGGAAGACTTGTGATTTTGTTGT	23	chr17	+	56242988	56243098	aggagcggagtacgtgagccagtgctatgTGGAAGACTTGTGATTTTGTTGTtctgatatgatatgacaacaagtcacagccagcctcatagcgtggactcctatcacctt	3	mmu-mir-7b,rno-mir-7b,cgr-mir-7b,	mmu-mir-7b	aggagcggagtacgtgagccagtgctatgTGGAAGACTTGTGATTTTGTTGTtctgatatgatatgaCAACAAGTCACAGCCAGCCTCAtagcgtggactcctatcacctt	mmu-miR-7b-5p	TGGAAGACTTGTGATTTTGTTGT	5'	Yes	gp1a	(((.(((.....)))((((((.(((((((.((.....(((((((((.(((((..((......))..))))))))))))))....)).)))))))))).)))......))).	86	46.80	-35.80	7	8	6	6	9	0	12	6	0	0	0	0	5	24	0	8.26	9.07	4.85	7.56	8.59	0	13.17	5.22	0	0	0	0	6.07	17.48	0	middle
9	13	mmu-let-7f-5p	TGAGGTAGTAGATTGTATAGTT	22	chr13	-	48537811	48537940	attccagaagaaaaacttgctctatcagagTGAGGTAGTAGATTGTATAGTTgtggggtagtgattttaccctgtttaggagataaCTATACAATCTATTGCCTTCCCtgaggagtagacttgctgcatt	18	mmu-let-7f-1,rno-let-7f-1,cgr-let-7f,hsa-let-7f-1,bta-let-7f-1,ppy-let-7f-1,mml-let-7f-1,mdo-let-7f-1,eca-let-7f,ptr-let-7f-1,cfa-let-7f,tch-let-7f,efu-let-7f,ssc-let-7f-2,ggo-let-7f,chi-let-7f,gga-let-7f,tgu-let-7f,	mmu-let-7f-1	atcagagTGAGGTAGTAGATTGTATAGTTgtggggtagtgattttaccctgtttaggagataaCTATACAATCTATTGCCTTCCCtgag	mmu-let-7f-5p	TGAGGTAGTAGATTGTATAGTT	5'	Yes	gp1a	....((((((......(((((((.((((...((((((((((((((((((((((((((((((.....))))))).........)))))))))))))))))))))))..))))))))))).))).)))....	122	39.20	-50.30	223988.23	224054.36	310075.11	216241.50	263199.10	228574.61	227177.07	309683.24	224084.71	239972.10	295836.61	253926.48	194858.84	350808.30	318058.70	264293.29	253920.74	250625.22	272512.21	251298.92	255122.81	249413.40	269217.69	252858.46	230475.18	266171.12	250288.34	236580.07	255478.01	263400.01	high
9	14	mmu-let-7f-1-3p_1ss22CT	CTATACAATCTATTGCCTTCCT	22	chr13	-	48537811	48537940	attccagaagaaaaacttgctctatcagagTGAGGTAGTAGATTGTATAGTTgtggggtagtgattttaccctgtttaggagataaCTATACAATCTATTGCCTTCCCtgaggagtagacttgctgcatt	18	mmu-let-7f-1,rno-let-7f-1,cgr-let-7f,hsa-let-7f-1,bta-let-7f-1,ppy-let-7f-1,mml-let-7f-1,mdo-let-7f-1,eca-let-7f,ptr-let-7f-1,cfa-let-7f,tch-let-7f,efu-let-7f,ssc-let-7f-2,ggo-let-7f,chi-let-7f,gga-let-7f,tgu-let-7f,	mmu-let-7f-1	atcagagTGAGGTAGTAGATTGTATAGTTgtggggtagtgattttaccctgtttaggagataaCTATACAATCTATTGCCTTCCCtgag	mmu-let-7f-1-3p	CTATACAATCTATTGCCTTCCC	3'	Diff	gp1a	....((((((......(((((((.((((...((((((((((((((((((((((((((((((.....))))))).........)))))))))))))))))))))))..))))))))))).))).)))....	122	39.20	-50.30	513	384	629	380	593	395	525	564	402	594	637	591	383	625	573	605.31	435.19	508.40	478.88	566.19	440.88	576.39	490.30	453.62	570.49	573.12	582.53	465.00	455.16	474.53	middle
10	15	mmu-let-7j_R-1_1ss8TG	TGAGGTAGTAGTTTGTGCTGTTA	23	chr3	+	140028249	140028370	attggaggctatttctgatcatgataatttccTGAGGTATTAGTTTGTGCTGTTAtatgaatcgaataatatcccttgctcagattaaaagcctggagttaaaaaaatcaagtgccttgaac	1	mmu-let-7j,	mmu-let-7j	attggaggctatttctgatcatgataatttccTGAGGTATTAGTTTGTGCTGTTATatgaatcgaataatatcccttgctcagattaaaagcctggagttaaaaaaatcaagtgccttgaac	mmu-let-7j	TGAGGTATTAGTTTGTGCTGTTAT	5'	Diff	gp1a	....(((((.(((..((((.....(((((((...((((.((((((((.((....((((..........)))).....)).))))))))..))))))))))).....))))))))))))....	114	34.40	-23.30	3713.50	3786.50	4993	3651	4381.50	4309	4171.50	5551.50	3637	4194	4615.50	4545.50	3312	5772	4976.50	4381.72	4291.24	4035.71	4601.07	4183.40	4809.48	4579.81	4826.10	4104.01	4028.02	4152.67	4480.37	4021.13	4203.49	4121.28	middle
11	16	mmu-let-7a-5p	TGAGGTAGTAGGTTGTATAGTT	22	chr9	+	41536716	41536812	ctgcatgttcccaggtTGAGGTAGTAGGTTGTATAGTTtagagttacatcaagggagataaCTGTACAGCCTCCTAGCTTTCCttgggacttgcaca	13	mmu-let-7a-2,rno-let-7a-2,hsa-let-7a-2,bta-let-7a-2,eca-let-7a,ppy-let-7a-2,ptr-let-7a-2,mml-let-7a-2,cfa-let-7a-2,mdo-let-7a-2,ssc-let-7a-1,gga-let-7a-2,tgu-let-7a-2,	mmu-let-7a-2	ctgcatgttcccaggtTGAGGTAGTAGGTTGTATAGTTtagagttacatcaagggagataaCTGTACAGCCTCCTAGCTTTCcttgggacttgcac	mmu-let-7a-5p	TGAGGTAGTAGGTTGTATAGTT	5'	Yes	gp1a	.((((.(.(((((((..(((.(((.(((((((((((((.........(((......)))))))))))))))).))).)))..)))))))).))))..	94	45.40	-41.10	98639.42	94202.88	137356.73	89197.09	106817.52	96001.56	95779.28	125896.74	96625.36	107807.40	127633.44	118942.68	85914.39	151662.25	139922.05	116388.86	106760.09	111021.68	112408.09	101987.91	107151.83	105154.26	109446.12	109032.61	103540.91	114834.80	117238.52	104309.52	110448.84	115876.32	high
11	17	mmu-let-7a-2-3p_R+1	CTGTACAGCCTCCTAGCTTTCC	22	chr9	+	41536716	41536812	ctgcatgttcccaggtTGAGGTAGTAGGTTGTATAGTTtagagttacatcaagggagataaCTGTACAGCCTCCTAGCTTTCCttgggacttgcaca	13	mmu-let-7a-2,rno-let-7a-2,hsa-let-7a-2,bta-let-7a-2,eca-let-7a,ppy-let-7a-2,ptr-let-7a-2,mml-let-7a-2,cfa-let-7a-2,mdo-let-7a-2,ssc-let-7a-1,gga-let-7a-2,tgu-let-7a-2,	mmu-let-7a-2	ctgcatgttcccaggtTGAGGTAGTAGGTTGTATAGTTtagagttacatcaagggagataaCTGTACAGCCTCCTAGCTTTCcttgggacttgcac	mmu-let-7a-2-3p	CTGTACAGCCTCCTAGCTTTC	3'	Diff	gp1a	.((((.(.(((((((..(((.(((.(((((((((((((.........(((......)))))))))))))))).))).)))..)))))))).))))..	94	45.40	-41.10	0	0	0	0	7	0	0	10	0	0	0	5	0	0	0	0	0	0	0	6.68	0	0	8.69	0	0	0	4.93	0	0	0	low
12	18	mmu-let-7g-5p	TGAGGTAGTAGTTTGTACAGTT	22	chr9	+	106178827	106178932	cttttgcctgattccaggcTGAGGTAGTAGTTTGTACAGTTtgagggtctatgataccacccggtacaggagataaCTGTACAGGCCACTGCCTTGCCaggaacag	21	mmu-let-7g,rno-let-7g,eca-let-7g,cgr-let-7g,hsa-let-7g,ppy-let-7g,mml-let-7g,bta-let-7g,ptr-let-7g,mdo-let-7g,oar-let-7g,gga-let-7g,cfa-let-7g,tch-let-7g,oan-let-7g,ssc-let-7g,ggo-let-7g,chi-let-7g,tgu-let-7g-1,tgu-let-7g-2,xtr-let-7g,	mmu-let-7g	ccaggcTGAGGTAGTAGTTTGTACAGTTtgagggtctatgataccacccggtacaggagataACTGTACAGGCCACTGCCTTGCcagg	mmu-let-7g-5p	TGAGGTAGTAGTTTGTACAGTT	5'	Yes	gp1a	.......(((.((((.(((.((((((((.(..(((((((((.....((((.((.((((....))))))..)))))))))))))..).))))))))))).)))))))	99	50	-45.90	347981.50	357863.91	484141.81	334419.90	401024.85	339955.28	348518.37	484052.18	345706.55	374166.47	444641.58	382631.48	292987.13	515333.09	453415.15	410598.24	405567.06	391318.57	421443.18	382893.06	379439.98	382631.72	420802.26	390097.22	359358.79	400054.43	377149.32	355718.60	375294.05	375495.33	high
12	19	mmu-let-7g-3p_L-1R+1	CTGTACAGGCCACTGCCTTGCT	22	chr9	+	106178827	106178932	cttttgcctgattccaggcTGAGGTAGTAGTTTGTACAGTTtgagggtctatgataccacccggtacaggagataaCTGTACAGGCCACTGCCTTGCCaggaacag	21	mmu-let-7g,rno-let-7g,eca-let-7g,cgr-let-7g,hsa-let-7g,ppy-let-7g,mml-let-7g,bta-let-7g,ptr-let-7g,mdo-let-7g,oar-let-7g,gga-let-7g,cfa-let-7g,tch-let-7g,oan-let-7g,ssc-let-7g,ggo-let-7g,chi-let-7g,tgu-let-7g-1,tgu-let-7g-2,xtr-let-7g,	mmu-let-7g	ccaggcTGAGGTAGTAGTTTGTACAGTTtgagggtctatgataccacccggtacaggagataACTGTACAGGCCACTGCCTTGCcagg	mmu-let-7g-3p	ACTGTACAGGCCACTGCCTTGC	3'	Diff	gp1a	.......(((.((((.(((.((((((((.(..(((((((((.....((((.((.((((....))))))..)))))))))))))..).))))))))))).)))))))	99	50	-45.90	256	220	345	182	336	225	246	382	243	262	309	215	238	514	394	302.07	249.33	278.85	229.36	320.81	251.13	270.08	332.08	274.20	251.63	278.01	211.92	288.96	374.32	326.29	middle
13	20	mmu-let-7c-5p	TGAGGTAGTAGGTTGTATGGTT	22	chr15	+	85706598	85706704	gactgacggcctttggggTGAGGTAGTAGGTTGTATGGTTttgggctctgccccgctctgcggtaaCTATACAATCTACTGTCTTTCCtgaagtggccgcaatatct	14	mmu-let-7c-2,rno-let-7c-2,hsa-let-7a-3,bta-let-7a-3,ppy-let-7a-3,mml-let-7a-3,eca-let-7a-2,ptr-let-7a-3,cfa-let-7a-1,ggo-let-7a,chi-let-7a,gga-let-7a-3,tgu-let-7a-1,xtr-let-7e-2,	mmu-let-7c-2	acggcctttggggTGAGGTAGTAGGTTGTATGGTTttgggctctgccccgctctgcggtaaCTATACAATCTACTGTCTTTCCtgaagtggccgc	mmu-let-7c-5p	TGAGGTAGTAGGTTGTATGGTT	5'	Yes	gp1a	...((.((((((((..((..((..((((((((((((((((..((((...))))(((...)))..))))))))))))))))..))..))..))).)))))))......	98	51.40	-47.70	256014.92	238300.05	359463.89	224975.42	262720.02	244497.40	249622.12	316377.41	242901.86	278146.57	327210.28	313292.84	220474.06	383505.75	360616.05	302082.94	270065.37	290544.83	283518.88	250841.49	272894.97	274055.40	275037.15	274091.83	267138.89	294398.74	308804.14	267679.76	279290.10	298643.84	high
13	21	mmu-let-7c-2-3p	CTATACAATCTACTGTCTTTCC	22	chr15	+	85706598	85706704	gactgacggcctttggggTGAGGTAGTAGGTTGTATGGTTttgggctctgccccgctctgcggtaaCTATACAATCTACTGTCTTTCCtgaagtggccgcaatatct	14	mmu-let-7c-2,rno-let-7c-2,hsa-let-7a-3,bta-let-7a-3,ppy-let-7a-3,mml-let-7a-3,eca-let-7a-2,ptr-let-7a-3,cfa-let-7a-1,ggo-let-7a,chi-let-7a,gga-let-7a-3,tgu-let-7a-1,xtr-let-7e-2,	mmu-let-7c-2	acggcctttggggTGAGGTAGTAGGTTGTATGGTTttgggctctgccccgctctgcggtaaCTATACAATCTACTGTCTTTCCtgaagtggccgc	mmu-let-7c-2-3p	CTATACAATCTACTGTCTTTCC	3'	Yes	gp1a	...((.((((((((..((..((..((((((((((((((((..((((...))))(((...)))..))))))))))))))))..))..))..))).)))))))......	98	51.40	-47.70	949.50	764.50	1284.50	793	1107.50	916	1000	1244	888.50	1014.50	1309.50	1024.50	740	1461.50	1270	1120.36	866.41	1038.23	999.36	1057.43	1022.39	1097.88	1081.45	1002.59	974.35	1178.19	1009.82	898.44	1064.35	1051.75	middle
14	22	mmu-miR-7a-5p_R+1	TGGAAGACTAGTGATTTTGTTGTT	24	chr7	+	78888277	78888373	ggtcgggccagccccgttTGGAAGACTAGTGATTTTGTTGTTgtgtctctgtatccaacaacaagtcccagtctgccacatggtgctggtcatttca	6	mmu-mir-7a-2,rno-mir-7a-2,eca-mir-7-1,cfa-mir-7-2,ssc-mir-7-1,tch-mir-7-2,	mmu-mir-7a-2	ggtcgggccagccccgttTGGAAGACTAGTGATTTTGTTGTtgtgtctctgtatccaaCAACAAGTCCCAGTCTGCCACAtggtgctggtcatttca	mmu-miR-7a-5p	TGGAAGACTAGTGATTTTGTTGT	5'	Diff	gp1a	((...(((((((.((((.(((.(((((...((.((((((((((..(......)..))))))))))))..))))).))).)))).)))))))...)).	96	50.50	-40.30	1695.50	1854.50	2230.50	1748.50	2500	1986.50	2013.50	2702.50	1702.50	2202.50	2243.50	2135.50	1577	3062.50	2642.50	2000.59	2101.70	1802.85	2203.50	2386.97	2217.23	2210.58	2349.37	1921.11	2115.34	2018.53	2104.90	1914.65	2230.28	2188.38	middle
15	23	mmu-let-7c-5p	TGAGGTAGTAGGTTGTATGGTT	22	chr16	+	77599630	77599774	taaggagtttgaagaaacattggaagctgtgtgcatccgggtTGAGGTAGTAGGTTGTATGGTTtagagttacaccctgggagttaaCTGTACAACCTTCTAGCTTTCCttggagcacacttgagccatcgaggaattctccatc	21	mmu-let-7c-1,rno-let-7c-1,cgr-let-7c,hsa-let-7c,bta-let-7c,ppy-let-7c,mml-let-7c,oar-let-7c,gga-let-7c,eca-let-7c,ptr-let-7c,cfa-let-7c,efu-let-7c,oan-let-7c-1,oan-let-7c-2,ssc-let-7c,ggo-let-7c,chi-let-7c,tgu-let-7c-1,tgu-let-7c-2,xtr-let-7c,	mmu-let-7c-1	tgtgtgcatccgggtTGAGGTAGTAGGTTGTATGGTTtagagttacaccctgggagttaaCTGTACAACCTTCTAGCTTTCCttggagcacact	mmu-let-7c-5p	TGAGGTAGTAGGTTGTATGGTT	5'	Yes	gp1a	...((((.............(((.....((((((.(((..(..(((.(((.((((((((..(((..((.(..(.....)..).)))))..)))))))).))).)))..)..))))))))).....)))..........))))...	108	45.50	-50.60	256014.92	238300.05	359463.89	224975.42	262720.02	244497.40	249622.12	316377.41	242901.86	278146.57	327210.28	313292.84	220474.06	383505.75	360616.05	302082.94	270065.37	290544.83	283518.88	250841.49	272894.97	274055.40	275037.15	274091.83	267138.89	294398.74	308804.14	267679.76	279290.10	298643.84	high
15	24	mmu-let-7c-1-3p	CTGTACAACCTTCTAGCTTTCC	22	chr16	+	77599630	77599774	taaggagtttgaagaaacattggaagctgtgtgcatccgggtTGAGGTAGTAGGTTGTATGGTTtagagttacaccctgggagttaaCTGTACAACCTTCTAGCTTTCCttggagcacacttgagccatcgaggaattctccatc	21	mmu-let-7c-1,rno-let-7c-1,cgr-let-7c,hsa-let-7c,bta-let-7c,ppy-let-7c,mml-let-7c,oar-let-7c,gga-let-7c,eca-let-7c,ptr-let-7c,cfa-let-7c,efu-let-7c,oan-let-7c-1,oan-let-7c-2,ssc-let-7c,ggo-let-7c,chi-let-7c,tgu-let-7c-1,tgu-let-7c-2,xtr-let-7c,	mmu-let-7c-1	tgtgtgcatccgggtTGAGGTAGTAGGTTGTATGGTTtagagttacaccctgggagttaaCTGTACAACCTTCTAGCTTTCCttggagcacact	mmu-let-7c-1-3p	CTGTACAACCTTCTAGCTTTCC	3'	Yes	gp1a	...((((.............(((.....((((((.(((..(..(((.(((.((((((((..(((..((.(..(.....)..).)))))..)))))))).))).)))..)..))))))))).....)))..........))))...	108	45.50	-50.60	66	26	172	98	144	109	98	139	81	85	143	113	51	119	96	77.88	29.47	139.02	123.50	137.49	121.66	107.59	120.84	91.40	81.64	128.66	111.38	61.92	86.66	79.50	middle
16	25	mmu-let-7k_R+1_1ss9GT	TGAGGTAGTAGGTTGTGTGC	20	chr5	-	147283189	147283298	tagccacagccctaaccctagccTGAGGTAGGAGGTTGTGTGCaagctcaccactaacctatagtacacagagagcctttatcccacaacacaacacaaaacaatacttc	1	mmu-let-7k,	mmu-let-7k	tagccacagccctaaccctagccTGAGGTAGGAGGTTGTGTGcaagctcaccactaacctatagtacacagagagcctttatcccacaacacaacacaaaacaatacttc	mmu-let-7k	TGAGGTAGGAGGTTGTGTG	5'	Diff	gp1a	..((((((((((..(((.........)))..).))))))).))..((((...((((.....)))).......))))..................................	41	47.30	-20.70	0	0	4	0	0	0	0	0	0	0	0	0	2.50	0	2.50	0	0	3.23	0	0	0	0	0	0	0	0	0	3.04	0	2.07	low
17	26	mmu-let-7f-5p	TGAGGTAGTAGATTGTATAGTT	22	chrX	+	151912346	151912428	tgtgggaTGAGGTAGTAGATTGTATAGTTttagggtcataccccatcttggagataaCTATACAGTCTACTGTCTTTCCcacg	11	mmu-let-7f-2,rno-let-7f-2,hsa-let-7f-2,bta-let-7f-2,ppy-let-7f-2,mml-let-7f-2,ssc-let-7f-1,oar-let-7f,ptr-let-7f-2,mdo-let-7f-2,xtr-let-7f,	mmu-let-7f-2	tgtgggaTGAGGTAGTAGATTGTATAGTTttagggtcataccccatcttggagataaCTATACAGTCTACTGTCTTTCccacg	mmu-let-7f-5p	TGAGGTAGTAGATTGTATAGTT	5'	Yes	gp1a	.((((((.(((..((((((((((((((((...(((.....))).(((.....)))))))))))))))))))..))))))))).	81	42.20	-40.70	223988.23	224054.36	310075.11	216241.50	263199.10	228574.61	227177.07	309683.24	224084.71	239972.10	295836.61	253926.48	194858.84	350808.30	318058.70	264293.29	253920.74	250625.22	272512.21	251298.92	255122.81	249413.40	269217.69	252858.46	230475.18	266171.12	250288.34	236580.07	255478.01	263400.01	high
17	27	mmu-let-7f-2-3p_R+1	CTATACAGTCTACTGTCTTTCT	22	chrX	+	151912346	151912428	tgtgggaTGAGGTAGTAGATTGTATAGTTttagggtcataccccatcttggagataaCTATACAGTCTACTGTCTTTCCcacg	11	mmu-let-7f-2,rno-let-7f-2,hsa-let-7f-2,bta-let-7f-2,ppy-let-7f-2,mml-let-7f-2,ssc-let-7f-1,oar-let-7f,ptr-let-7f-2,mdo-let-7f-2,xtr-let-7f,	mmu-let-7f-2	tgtgggaTGAGGTAGTAGATTGTATAGTTttagggtcataccccatcttggagataaCTATACAGTCTACTGTCTTTCccacg	mmu-let-7f-2-3p	CTATACAGTCTACTGTCTTTC	3'	Diff	gp1a	.((((((.(((..((((((((((((((((...(((.....))).(((.....)))))))))))))))))))..))))))))).	81	42.20	-40.70	379.50	311.50	522	309.50	425	375	401.50	428.50	338.50	411.50	519.50	401	312	601.50	549.50	447.79	353.02	421.92	390.04	405.78	418.56	440.80	372.51	381.97	395.21	467.41	395.25	378.80	438.05	455.07	middle
18	28	mmu-miR-7a-5p_R+1	TGGAAGACTAGTGATTTTGTTGTT	24	chr13	-	58392775	58392920	ttatacagagcctgtagaaaatgtagaagagacattggatgttggcctagttctgtgTGGAAGACTAGTGATTTTGTTGTTtttagataactaaaacgaCAACAAATCACAGTCTGCCATAtggcacaggccacctctacaggaca	26	mmu-mir-7a-1,rno-mir-7a-1,hsa-mir-7-1,ppy-mir-7-1,ggo-mir-7-1,ppa-mir-7-1,lla-mir-7,bta-mir-7-2,eca-mir-7-3,ptr-mir-7-1,mml-mir-7-1,mne-mir-7-1,cfa-mir-7-1,tch-mir-7-3,tch-mir-7-4,efu-mir-7b,mdo-mir-7,oan-mir-7-1,ssc-mir-7-2,aja-mir-7,chi-mir-7,sha-mir-7,sla-mir-7,gga-mir-7-1,tgu-mir-7-1,xtr-mir-7-1,	mmu-mir-7a-1	ttggatgttggcctagttctgtgTGGAAGACTAGTGATTTTGTTGTttttagataactaaaacgaCAACAAATCACAGTCTGCCATAtggcacaggccacctctacag	mmu-miR-7a-5p	TGGAAGACTAGTGATTTTGTTGT	5'	Diff	gp1a	..........((((((((.(((((.......)))))......((((((.((.(..(((((.(((((.((((.((((((((((((((....)))))..)))))))))))))))))).)))))..).))))))))..))))))))...	91	40.40	-58.10	1695.50	1854.50	2230.50	1748.50	2500	1986.50	2013.50	2702.50	1702.50	2202.50	2243.50	2135.50	1577	3062.50	2642.50	2000.59	2101.70	1802.85	2203.50	2386.97	2217.23	2210.58	2349.37	1921.11	2115.34	2018.53	2104.90	1914.65	2230.28	2188.38	middle
18	29	mmu-miR-7a-1-3p	CAACAAATCACAGTCTGCCATA	22	chr13	-	58392775	58392920	ttatacagagcctgtagaaaatgtagaagagacattggatgttggcctagttctgtgTGGAAGACTAGTGATTTTGTTGTTtttagataactaaaacgaCAACAAATCACAGTCTGCCATAtggcacaggccacctctacaggaca	26	mmu-mir-7a-1,rno-mir-7a-1,hsa-mir-7-1,ppy-mir-7-1,ggo-mir-7-1,ppa-mir-7-1,lla-mir-7,bta-mir-7-2,eca-mir-7-3,ptr-mir-7-1,mml-mir-7-1,mne-mir-7-1,cfa-mir-7-1,tch-mir-7-3,tch-mir-7-4,efu-mir-7b,mdo-mir-7,oan-mir-7-1,ssc-mir-7-2,aja-mir-7,chi-mir-7,sha-mir-7,sla-mir-7,gga-mir-7-1,tgu-mir-7-1,xtr-mir-7-1,	mmu-mir-7a-1	ttggatgttggcctagttctgtgTGGAAGACTAGTGATTTTGTTGTttttagataactaaaacgaCAACAAATCACAGTCTGCCATAtggcacaggccacctctacag	mmu-miR-7a-1-3p	CAACAAATCACAGTCTGCCATA	3'	Yes	gp1a	..........((((((((.(((((.......)))))......((((((.((.(..(((((.(((((.((((.((((((((((((((....)))))..)))))))))))))))))).)))))..).))))))))..))))))))...	91	40.40	-58.10	313	350	450	285	405	334	345	418	335	364	433	396	282	513	465	369.32	396.65	363.72	359.16	386.69	372.79	378.77	363.38	378.02	349.59	389.58	390.33	342.38	373.59	385.09	middle
19	30	mmu-let-7a-5p	TGAGGTAGTAGGTTGTATAGTT	22	chr13	-	48538171	48538272	ttcactgtgggaTGAGGTAGTAGGTTGTATAGTTttagggtcacacccaccactgggagataaCTATACAATCTACTGTCTTTCCtaaggtgatggaaaagt	14	mmu-let-7a-1,rno-let-7a-1,cgr-let-7a,hsa-let-7a-1,bta-let-7a-1,ppy-let-7a-1,mml-let-7a-1,ptr-let-7a-1,mdo-let-7a-1,ssc-let-7a-2,oar-let-7a,gga-let-7a-1,tgu-let-7a-3,xtr-let-7e-1,	mmu-let-7a-1	ttcactgtgggaTGAGGTAGTAGGTTGTATAGTTttagggtcacacccaccactgggagataaCTATACAATCTACTGTCTTTCCtaaggtgat	mmu-let-7a-5p	TGAGGTAGTAGGTTGTATAGTT	5'	Yes	gp1a	.((((..(((((.(((..((((((((((((((((...(((.....))).((....))....))))))))))))))))..))))))))..)))).........	92	42.20	-43.20	98639.42	94202.88	137356.73	89197.09	106817.52	96001.56	95779.28	125896.74	96625.36	107807.40	127633.44	118942.68	85914.39	151662.25	139922.05	116388.86	106760.09	111021.68	112408.09	101987.91	107151.83	105154.26	109446.12	109032.61	103540.91	114834.80	117238.52	104309.52	110448.84	115876.32	high
19	31	mmu-let-7c-2-3p_1ss22CT	CTATACAATCTACTGTCTTTCT	22	chr13	-	48538171	48538272	ttcactgtgggaTGAGGTAGTAGGTTGTATAGTTttagggtcacacccaccactgggagataaCTATACAATCTACTGTCTTTCCtaaggtgatggaaaagt	14	mmu-let-7a-1,rno-let-7a-1,cgr-let-7a,hsa-let-7a-1,bta-let-7a-1,ppy-let-7a-1,mml-let-7a-1,ptr-let-7a-1,mdo-let-7a-1,ssc-let-7a-2,oar-let-7a,gga-let-7a-1,tgu-let-7a-3,xtr-let-7e-1,	mmu-let-7a-1	ttcactgtgggaTGAGGTAGTAGGTTGTATAGTTttagggtcacacccaccactgggagataaCTATACAATCTACTGTCTTTCCtaaggtgat	mmu-let-7c-2-3p	CTATACAATCTACTGTCTTTCC	3'	Diff	gp1a	.((((..(((((.(((..((((((((((((((((...(((.....))).((....))....))))))))))))))))..))))))))..)))).........	92	42.20	-43.20	3381	2650	4267.50	2821.50	3906.50	3154	3380.50	4303.50	2932	3536	4314	3636.50	2574	5306	4422.50	3989.39	3003.24	3449.30	3555.72	3729.87	3520.33	3711.39	3741.17	3308.49	3396.06	3881.41	3584.40	3125.12	3864.12	3662.49	middle
20	32	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	23	chr7	+	79505240	79505369	gcgcggcagcggtgccggcgaatgggaggcccgtttctcTCTTTGGTTATCTAGCTGTATGAgtgccacagagccgtcaTAAAGCTAGATAACCGAAAGTagaaatgactctcacaacttctgcgtgcga	14	mmu-mir-9-3,bta-mir-9-1,ppy-mir-9-3,rno-mir-9a-3,hsa-mir-9-3,mml-mir-9-3,cfa-mir-9-3,tch-mir-9-2,efu-mir-9-2,mdo-mir-9a-1,ssc-mir-9-3,chi-mir-9,tgu-mir-9-1,xtr-mir-9-3,	mmu-mir-9-3	ggaggcccgtttctcTCTTTGGTTATCTAGCTGTATGAgtgccacagagccgtcATAAAGCTAGATAACCGAAAGTagaaatgactctca	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	5'	Yes	gp1a	((((.((((..((.(((.....)))((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..))))...))..))))))))..	88	53.10	-55	1756.67	1886.67	2398.67	2036	2176.33	1380	1415.67	2298.33	1731.67	1791.67	2047.67	1864	1511	3006.67	2473.67	2072.77	2138.16	1938.78	2565.81	2077.93	1540.28	1554.23	1998.02	1954.02	1720.76	1842.33	1837.29	1834.52	2189.62	2048.56	middle
20	33	mmu-miR-9-3p_L-1	TAAAGCTAGATAACCGAAAGT	21	chr7	+	79505240	79505369	gcgcggcagcggtgccggcgaatgggaggcccgtttctcTCTTTGGTTATCTAGCTGTATGAgtgccacagagccgtcaTAAAGCTAGATAACCGAAAGTagaaatgactctcacaacttctgcgtgcga	14	mmu-mir-9-3,bta-mir-9-1,ppy-mir-9-3,rno-mir-9a-3,hsa-mir-9-3,mml-mir-9-3,cfa-mir-9-3,tch-mir-9-2,efu-mir-9-2,mdo-mir-9a-1,ssc-mir-9-3,chi-mir-9,tgu-mir-9-1,xtr-mir-9-3,	mmu-mir-9-3	ggaggcccgtttctcTCTTTGGTTATCTAGCTGTATGAgtgccacagagccgtcATAAAGCTAGATAACCGAAAGTagaaatgactctca	mmu-miR-9-3p	ATAAAGCTAGATAACCGAAAGT	3'	Diff	gp1a	((((.((((..((.(((.....)))((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..))))...))..))))))))..	88	53.10	-55	396.83	533.67	615.67	481.50	509.17	337.83	346.17	479.17	407.33	450.17	442.83	415	365.33	667.33	525.17	468.24	604.80	497.63	606.80	486.15	377.07	380.05	416.56	459.64	432.35	398.43	409.05	443.55	485.99	434.92	middle
21	34	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	23	chr3	+	88215585	88215702	ggcggccaggaggcggggttggttgttaTCTTTGGTTATCTAGCTGTATGAgtggtgtggagtcttcaTAAAGCTAGATAACCGAAAGTaaaaataaccccatacactgcgcagaggg	13	mmu-mir-9-1,rno-mir-9a-1,hsa-mir-9-1,ppy-mir-9-1,mml-mir-9-1,ssc-mir-9-1,eca-mir-9a,ptr-mir-9-1,cfa-mir-9-1,efu-mir-9-1,mdo-mir-9a-3,tch-mir-9-3,xtr-mir-9a-1,	mmu-mir-9-1	cggggttggttgttaTCTTTGGTTATCTAGCTGTATGAgtggtgtggagtcttcATAAAGCTAGATAACCGAAAGTaaaaataacccca	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	5'	Yes	gp1a	.(((..(((.....(((((((....(((..(((((((((((((((.((((((.((.......)))))))).)))))))))))))))..)))...))))))).....))))))......	111	48.30	-47.50	1756.67	1886.67	2398.67	2036	2176.33	1380	1415.67	2298.33	1731.67	1791.67	2047.67	1864	1511	3006.67	2473.67	2072.77	2138.16	1938.78	2565.81	2077.93	1540.28	1554.23	1998.02	1954.02	1720.76	1842.33	1837.29	1834.52	2189.62	2048.56	middle
21	35	mmu-miR-9-3p_L-1	TAAAGCTAGATAACCGAAAGT	21	chr3	+	88215585	88215702	ggcggccaggaggcggggttggttgttaTCTTTGGTTATCTAGCTGTATGAgtggtgtggagtcttcaTAAAGCTAGATAACCGAAAGTaaaaataaccccatacactgcgcagaggg	13	mmu-mir-9-1,rno-mir-9a-1,hsa-mir-9-1,ppy-mir-9-1,mml-mir-9-1,ssc-mir-9-1,eca-mir-9a,ptr-mir-9-1,cfa-mir-9-1,efu-mir-9-1,mdo-mir-9a-3,tch-mir-9-3,xtr-mir-9a-1,	mmu-mir-9-1	cggggttggttgttaTCTTTGGTTATCTAGCTGTATGAgtggtgtggagtcttcATAAAGCTAGATAACCGAAAGTaaaaataacccca	mmu-miR-9-3p	ATAAAGCTAGATAACCGAAAGT	3'	Diff	gp1a	.(((..(((.....(((((((....(((..(((((((((((((((.((((((.((.......)))))))).)))))))))))))))..)))...))))))).....))))))......	111	48.30	-47.50	396.83	533.67	615.67	481.50	509.17	337.83	346.17	479.17	407.33	450.17	442.83	415	365.33	667.33	525.17	468.24	604.80	497.63	606.80	486.15	377.07	380.05	416.56	459.64	432.35	398.43	409.05	443.55	485.99	434.92	middle
22	36	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	23	chr13	+	83738801	83738894	gtgagggaagcgagttgttaTCTTTGGTTATCTAGCTGTATGAgtgtattggtcttcaTAAAGCTAGATAACCGAAAGTaaaaactccttcaag	22	mmu-mir-9-2,rno-mir-9a-2,hsa-mir-9-2,bta-mir-9-2,ptr-mir-9-2,mml-mir-9-2,ssc-mir-9-2,ggo-mir-9,mne-mir-9,age-mir-9,lla-mir-9,cgr-mir-9,eca-mir-9a-2,ppy-mir-9-2,mdo-mir-9a-2,cfa-mir-9-2,efu-mir-9-3,oan-mir-9-2,tch-mir-9-1,gga-mir-9-2,tgu-mir-9-2,xtr-mir-9a-2,	mmu-mir-9-2	gttgttaTCTTTGGTTATCTAGCTGTATGAgtgtattggtcttcATAAAGCTAGATAACCGAAAGTaaaaac	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	5'	Yes	gp1a	......((((.(((((.(((..(((((((((((((((.((((((..(....)..)))))).)))))))))))))))..))).)))))))))...	85	38.30	-40.10	1756.67	1886.67	2398.67	2036	2176.33	1380	1415.67	2298.33	1731.67	1791.67	2047.67	1864	1511	3006.67	2473.67	2072.77	2138.16	1938.78	2565.81	2077.93	1540.28	1554.23	1998.02	1954.02	1720.76	1842.33	1837.29	1834.52	2189.62	2048.56	middle
22	37	mmu-miR-9-3p_L-1	TAAAGCTAGATAACCGAAAGT	21	chr13	+	83738801	83738894	gtgagggaagcgagttgttaTCTTTGGTTATCTAGCTGTATGAgtgtattggtcttcaTAAAGCTAGATAACCGAAAGTaaaaactccttcaag	22	mmu-mir-9-2,rno-mir-9a-2,hsa-mir-9-2,bta-mir-9-2,ptr-mir-9-2,mml-mir-9-2,ssc-mir-9-2,ggo-mir-9,mne-mir-9,age-mir-9,lla-mir-9,cgr-mir-9,eca-mir-9a-2,ppy-mir-9-2,mdo-mir-9a-2,cfa-mir-9-2,efu-mir-9-3,oan-mir-9-2,tch-mir-9-1,gga-mir-9-2,tgu-mir-9-2,xtr-mir-9a-2,	mmu-mir-9-2	gttgttaTCTTTGGTTATCTAGCTGTATGAgtgtattggtcttcATAAAGCTAGATAACCGAAAGTaaaaac	mmu-miR-9-3p	ATAAAGCTAGATAACCGAAAGT	3'	Diff	gp1a	......((((.(((((.(((..(((((((((((((((.((((((..(....)..)))))).)))))))))))))))..))).)))))))))...	85	38.30	-40.10	396.83	533.67	615.67	481.50	509.17	337.83	346.17	479.17	407.33	450.17	442.83	415	365.33	667.33	525.17	468.24	604.80	497.63	606.80	486.15	377.07	380.05	416.56	459.64	432.35	398.43	409.05	443.55	485.99	434.92	middle
23	38	mmu-miR-10a-5p_R-1	TACCCTGTAGATCCGAATTTGT	22	chr11	+	96317160	96317275	aagaagacctgtctgtcttctgtataTACCCTGTAGATCCGAATTTGTgtaaggaattttgtggtcaCAAATTCGTATCTAGGGGAATatgtagttgacataaacactccgctcat	20	mmu-mir-10a,rno-mir-10a,cgr-mir-10a,hsa-mir-10a,ggo-mir-10a,bta-mir-10a,oar-mir-10a,eca-mir-10a,ppy-mir-10a,ptr-mir-10a,mml-mir-10a,cfa-mir-10a,mdo-mir-10a,oan-mir-10a,ssc-mir-10a,chi-mir-10a,ppa-mir-10a,age-mir-10a,sla-mir-10a,gga-mir-10a,	mmu-mir-10a	gacctgtctgtcttctgtataTACCCTGTAGATCCGAATTTGTGtaaggaattttgtggtcaCAAATTCGTATCTAGGGGAATAtgtagttgacataaacactccgctca	mmu-miR-10a-5p	TACCCTGTAGATCCGAATTTGTG	5'	Diff	gp1a	.(((((((......))))))).(((((.((((.(((((.((((((((((................)))))))))).))))))))).)))))..(((......)))...........	69	38.80	-33.20	944488.50	893187.50	1071414	963528.50	1158644.50	821312	919515.50	1090818	849627	1098807.50	1158597	960418.50	900721.50	1549966	1221946	1114442.35	1012249.11	865994.61	1214259.40	1106257.99	916704.71	1009518.67	948283.48	958723.90	1055322.08	1042416.84	946658.10	1093574.98	1128770.96	1011953.42	high
23	39	mmu-miR-10a-3p_R-1	CAAATTCGTATCTAGGGGAAT	21	chr11	+	96317160	96317275	aagaagacctgtctgtcttctgtataTACCCTGTAGATCCGAATTTGTgtaaggaattttgtggtcaCAAATTCGTATCTAGGGGAATatgtagttgacataaacactccgctcat	20	mmu-mir-10a,rno-mir-10a,cgr-mir-10a,hsa-mir-10a,ggo-mir-10a,bta-mir-10a,oar-mir-10a,eca-mir-10a,ppy-mir-10a,ptr-mir-10a,mml-mir-10a,cfa-mir-10a,mdo-mir-10a,oan-mir-10a,ssc-mir-10a,chi-mir-10a,ppa-mir-10a,age-mir-10a,sla-mir-10a,gga-mir-10a,	mmu-mir-10a	gacctgtctgtcttctgtataTACCCTGTAGATCCGAATTTGTGtaaggaattttgtggtcaCAAATTCGTATCTAGGGGAATAtgtagttgacataaacactccgctca	mmu-miR-10a-3p	CAAATTCGTATCTAGGGGAATA	3'	Diff	gp1a	.(((((((......))))))).(((((.((((.(((((.((((((((((................)))))))))).))))))))).)))))..(((......)))...........	69	38.80	-33.20	3846	3852	5966	3672	5139	3601	4117	4976	4282	4312	4956	4461	3717	6325	5639	4538.06	4365.47	4822.15	4627.53	4906.65	4019.24	4519.98	4325.80	4831.83	4141.35	4459.03	4397.09	4512.85	4606.21	4669.93	middle
24	40	mmu-miR-10b-5p_R-1	TACCCTGTAGAACCGAATTTGT	22	chr2	+	74726051	74726157	gaggttgtaacgttgtctatataTACCCTGTAGAACCGAATTTGTgtggtacccacatagtcACAGATTCGATTCTAGGGGAATatatggtcgatgcaaaaacttca	23	mmu-mir-10b,rno-mir-10b,cgr-mir-10b,hsa-mir-10b,ppa-mir-10b,bta-mir-10b,eca-mir-10b,ppy-mir-10b,mml-mir-10b,ptr-mir-10b,cfa-mir-10b,mdo-mir-10b,oan-mir-10b,ssc-mir-10b,ggo-mir-10b,chi-mir-10b,tch-mir-10b-1,tch-mir-10b-2,oar-mir-10b,mne-mir-10b,gga-mir-10b,tgu-mir-10a,xtr-mir-10b,	mmu-mir-10b	tataTACCCTGTAGAACCGAATTTGTGtggtacccacatagtcaCAGATTCGATTCTAGGGGAATAta	mmu-miR-10b-5p	TACCCTGTAGAACCGAATTTGTG	5'	Diff	gp1a	((((((....(((((.((((((((.((((.(((((.((((((((((..((......))...)))))))))).))))))))).)))))))).)))))....)))))).	106	40.20	-43.40	516479.50	516543.50	576749	558929.50	633122.50	444558	467206.50	592326	440836	587832.50	603649	528695.50	474556.50	823388	616648	609416.24	585398.59	466170.43	704375.01	604496.74	496191.96	512937.18	514928.21	497441.83	564568.97	543117.14	521120.61	576163.79	599636.68	510676.46	high
24	41	mmu-miR-10b-3p_L+1R-1	ACAGATTCGATTCTAGGGGAAT	22	chr2	+	74726051	74726157	gaggttgtaacgttgtctatataTACCCTGTAGAACCGAATTTGTgtggtacccacatagtcACAGATTCGATTCTAGGGGAATatatggtcgatgcaaaaacttca	23	mmu-mir-10b,rno-mir-10b,cgr-mir-10b,hsa-mir-10b,ppa-mir-10b,bta-mir-10b,eca-mir-10b,ppy-mir-10b,mml-mir-10b,ptr-mir-10b,cfa-mir-10b,mdo-mir-10b,oan-mir-10b,ssc-mir-10b,ggo-mir-10b,chi-mir-10b,tch-mir-10b-1,tch-mir-10b-2,oar-mir-10b,mne-mir-10b,gga-mir-10b,tgu-mir-10a,xtr-mir-10b,	mmu-mir-10b	tataTACCCTGTAGAACCGAATTTGTGtggtacccacatagtcaCAGATTCGATTCTAGGGGAATAta	mmu-miR-10b-3p	CAGATTCGATTCTAGGGGAATA	3'	Diff	gp1a	((((((....(((((.((((((((.((((.(((((.((((((((((..((......))...)))))))))).))))))))).)))))))).)))))....)))))).	106	40.20	-43.40	1706	1753	2619	1695	2481	1511	1793	2256	1866	1842	2261	1852	1615	2643	2326	2012.98	1986.67	2116.87	2136.08	2368.83	1686.50	1968.50	1961.21	2105.60	1769.10	2034.27	1825.47	1960.79	1924.78	1926.27	middle
25	42	mmu-miR-15a-5p_R-1	TAGCAGCACATAATGGTTTGT	21	chr14	-	61632017	61632110	cccttggagtaaagTAGCAGCACATAATGGTTTGTggatgttgaaaaggtgCAGGCCATACTGTGCTGCCTCAaaatacaaggacctgatcttc	23	mmu-mir-15a,rno-mir-15a,cgr-mir-15a,hsa-mir-15a,bta-mir-15a,ppy-mir-15a,ptr-mir-15a,mml-mir-15a,ggo-mir-15a,ppa-mir-15a,mne-mir-15a,age-mir-15a,lla-mir-15a,sla-mir-15a,lca-mir-15a,eca-mir-15a,cfa-mir-15a,tch-mir-15a,mdo-mir-15a,oan-mir-15a,ssc-mir-15a,chi-mir-15a,xtr-mir-15a,	mmu-mir-15a	cccttggagtaaagTAGCAGCACATAATGGTTTGTGgatgttgaaaaggtgCAGGCCATACTGTGCTGCCTCAaaatacaagga	mmu-miR-15a-5p	TAGCAGCACATAATGGTTTGTG	5'	Diff	gp1a	.(((((..........((((((((..((((..(((...............)))..))))..)))))))).........)))))...........	53	45.70	-29	12164	17094	19635	12188	15316	15009	13874	17556	16110	18923	16141	15820	13229	22255	18919	14352.82	19372.62	15870.43	15359.58	14623.51	16752.25	15232.00	15262.00	18178.61	18174.12	14522.44	15593.34	16061.46	16207.32	15667.75	high
25	43	mmu-miR-15a-3p_1ss22AT	CAGGCCATACTGTGCTGCCTCT	22	chr14	-	61632017	61632110	cccttggagtaaagTAGCAGCACATAATGGTTTGTggatgttgaaaaggtgCAGGCCATACTGTGCTGCCTCAaaatacaaggacctgatcttc	23	mmu-mir-15a,rno-mir-15a,cgr-mir-15a,hsa-mir-15a,bta-mir-15a,ppy-mir-15a,ptr-mir-15a,mml-mir-15a,ggo-mir-15a,ppa-mir-15a,mne-mir-15a,age-mir-15a,lla-mir-15a,sla-mir-15a,lca-mir-15a,eca-mir-15a,cfa-mir-15a,tch-mir-15a,mdo-mir-15a,oan-mir-15a,ssc-mir-15a,chi-mir-15a,xtr-mir-15a,	mmu-mir-15a	cccttggagtaaagTAGCAGCACATAATGGTTTGTGgatgttgaaaaggtgCAGGCCATACTGTGCTGCCTCAaaatacaagga	mmu-miR-15a-3p	CAGGCCATACTGTGCTGCCTCA	3'	Diff	gp1a	.(((((..........((((((((..((((..(((...............)))..))))..)))))))).........)))))...........	53	45.70	-29	189	225	286	221	241	250	280	306	243	274	311	243	205	407	379	223.01	254.99	231.17	278.51	230.10	279.04	307.41	266.02	274.20	263.16	279.81	239.52	248.89	296.40	313.87	middle
26	44	mmu-miR-15b-5p	TAGCAGCACATCATGGTTTACA	22	chr3	+	69009756	69009853	ttggaaccttaaagtactgTAGCAGCACATCATGGTTTACAtactacagtcaagatgCGAATCATTATTTGCTGCTCTagaaatttaaggaaattcat	18	mmu-mir-15b,eca-mir-15b,rno-mir-15b,cgr-mir-15b,hsa-mir-15b,ppy-mir-15b,ptr-mir-15b,ggo-mir-15b,ppa-mir-15b,bta-mir-15b,mml-mir-15b,chi-mir-15b,mne-mir-15b,age-mir-15b,lla-mir-15b,cfa-mir-15b,tch-mir-15b,ssc-mir-15b,	mmu-mir-15b	ctgTAGCAGCACATCATGGTTTACAtactacagtcaagatgCGAATCATTATTTGCTGCTCTAg	mmu-miR-15b-5p	TAGCAGCACATCATGGTTTACA	5'	Yes	gp1a	.((((.(((((((...((..(((((((.((.((((((..(((.((.......)))))..)))))).)).)))))))..))...)))))))...)))).	96	34.70	-29.10	4534	5769	6200	4334	5066	4502	4282	5329	4073	5702	5238	5220	3827	5944	5385	5349.86	6538.01	5011.29	5461.80	4836.95	5024.89	4701.13	4632.67	4596.00	5476.34	4712.75	5145.21	4646.40	4328.75	4459.58	middle

document location: Final_Report/3_Summary/2_miRNAExpression/Table5_All_Expressed_miRNA.xlsx

4.3 Differentially expressed miRNAs

4.3.1 Profiling of differentially expressed miRNAs

Differential expression of miRNAs based on normalized deep-sequencing counts was analyzed by selectively using Fisher exact test, Chi-squared 2X2 test, Chi-squared nXn test, Student t test, or ANOVA based on the experiments design. The significance threshold was set to be 0.01 and 0.05 in each test.

Index	miR_name	miR_seq	up/down	fold_change(C_12MK(mean)/C_3MK(mean))	log2(fold_change)	pvalue(t_test)	C_3MK(mean)	C_12MK(mean)	C_12MK/C_12MK17(norm)	C_12MK/C_12MK18(norm)	C_12MK/C_12MK19(norm)	C_12MK/C_12MK20(norm)	C_12MK/C_12MK21(norm)	C_3MK/C_3MK5(norm)	C_3MK/C_3MK6(norm)	C_3MK/C_3MK7(norm)	C_3MK/C_3MK8(norm)	C_3MK/C_3MK9(norm)	C_12MK/C_12MK17(raw)	C_12MK/C_12MK18(raw)	C_12MK/C_12MK19(raw)	C_12MK/C_12MK20(raw)	C_12MK/C_12MK21(raw)	C_3MK/C_3MK5(raw)	C_3MK/C_3MK6(raw)	C_3MK/C_3MK7(raw)	C_3MK/C_3MK8(raw)	C_3MK/C_3MK9(raw)	Expression level
1	mmu-miR-335-3p	TTTTTCATTATTGCTCCTGACC	down	0.68	-0.55	0.00	479.99	326.78	313.64	332.66	336.43	322.72	328.47	455.46	502.05	424.34	501.57	516.54	281	303	387	286	342	386	443	525	398	541	middle
2	mmu-miR-200b-3p_R+1	TAATACTGCCTGGTAATGATGAC	down	0.93	-0.11	0.00	180528.84	167335.83	167322.11	168956.76	169744.12	165323.84	165332.34	180854.54	185882.11	182410.16	178732.82	174764.58	149910.50	153893.50	195258	146511	172145	153274	164018.50	225679	141826.50	183040.50	high
3	mmu-miR-378a-3p_R+1	ACTGGACTTGGAGTCAGAAGGC	down	0.90	-0.16	0.00	127591.39	114354.43	111184.21	111711.96	118075.78	119854.17	110946.04	130103.04	127374.57	121437.71	131806.15	127235.47	99614.33	101752.33	135823.50	106215.50	115517.67	110262.17	112392.67	150243.50	104589.67	133260.67	high
4	efu-miR-9226_L-4_1ss22GT	GTCCCTGTTCGGGCGCCT	up	7.49	2.91	0.00	0.97	7.27	7.81	6.59	9.56	5.64	6.72	0	0	4.85	0	0	7	6	11	5	7	0	0	6	0	0	low
5	mmu-miR-296-5p	AGGGCCCCCCCTCAATCCTGT	down	0.39	-1.35	0.00	29.18	11.41	20.09	12.08	8.69	5.64	10.56	27.14	27.20	23.44	28.99	39.15	18	11	10	5	11	23	24	29	23	41	middle
6	mmu-miR-144-3p_R-1	TACAGTATAGATGATGTAC	down	0.60	-0.74	0.00	10722.51	6405.07	6775.01	4952.54	5747.16	6949.85	7600.80	12697.36	11963.11	8502.22	10546.79	9903.04	6070	4511	6611	6159	7914	10761	10556	10519	8369	10372	middle
7	mmu-miR-375-3p	TTTGTTCGTTCGGCTCGCGTGA	up	1.38	0.47	0.00	1320.72	1823.26	2009.06	1984.97	1876.89	1658.76	1586.62	1195.28	1478.96	1538.14	1112.78	1278.46	1800	1808	2159	1470	1652	1013	1305	1903	883	1339	middle
8	mmu-miR-208a-3p	ATAAGACGAGCAAAAAGCTTGT	down	0.60	-0.74	0.00	58.37	35.07	35.72	24.15	33.03	44.01	38.42	56.64	58.93	57.39	45.37	73.52	32	22	38	39	40	48	52	71	36	77	middle
9	mmu-miR-124-3p	TAAGGCACGCGGTGAATGCC	up	31.74	4.99	0.00	14.96	474.70	263.04	600.54	313.25	593.54	603.15	17.31	13.98	10.51	31.09	1.91	235.67	547	360.33	526	628	14.67	12.33	13	24.67	2	middle
10	mmu-miR-592-5p_L-1	TTGTGTCAATATGCGATGATGT	up	3.31	1.73	0.00	3.32	11.00	15.63	9.88	7.82	10.16	11.53	5.90	0	4.04	0	6.68	14	9	9	9	12	5	0	5	0	7	middle
11	mmu-miR-486a-5p	TCCTGTACTGAGCTGCCCCGAG	down	0.46	-1.12	0.00	9162.65	4202.38	3967.90	3559.33	3376.49	4149.71	5958.48	9214.76	12626.66	6721.60	8227.99	9022.25	3555	3242	3884	3677.50	6204	7809.50	11141.50	8316	6529	9449.50	middle
12	mmu-miR-3058-5p_R-3	TCAGCCACGGCTTACCTGGA	down	0.64	-0.64	0.01	98.91	63.49	62.50	53.80	66.94	75.60	58.59	100.30	70.26	104.27	110.90	108.85	56	49	77	67	61	85	62	129	88	114	middle
13	mmu-miR-511-3p	AATGTGTAGCAAAAGACAGGAT	up	1.90	0.92	0.01	141.06	267.43	299.13	323.87	297.31	232.45	184.40	97.94	117.86	192.37	107.12	190.00	268	295	342	206	192	83	104	238	85	199	middle
14	mmu-miR-199b-5p_1ss10TC	CCCAGTGTTCAGACTACCTGTTC	up	1.42	0.50	0.01	28553.94	40491.54	39260.83	50260.26	39432.63	37686.87	35817.13	25466.31	30048.69	33021.44	25595.10	28638.18	35175.33	45779.33	45359.67	33398.33	37293	21582.67	26514.33	40854.33	20310	29994.33	high
15	mmu-miR-199a-5p	CCCAGTGTTCAGACTACCTGTTC	up	1.42	0.50	0.01	28553.94	40491.54	39260.83	50260.26	39432.63	37686.87	35817.13	25466.31	30048.69	33021.44	25595.10	28638.18	35175.33	45779.33	45359.67	33398.33	37293	21582.67	26514.33	40854.33	20310	29994.33	high
16	mmu-miR-542-3p_R-2	TGTGACAGATTGATAACTGA	down	0.82	-0.28	0.01	652.41	537.13	481.06	533.57	550.29	580.00	540.72	664.31	678.85	599.74	723.37	595.79	431	486	633	514	563	563	599	742	574	624	middle
17	mmu-miR-335-5p_R-2	TCAAGAGCAATAACGAAAAAT	down	0.71	-0.50	0.01	4199.32	2978.76	2837.24	2874.25	2975.72	3015.10	3191.49	4341.01	4220.41	3329.27	4837.99	4267.90	2542	2618	3423	2672	3323	3679	3724	4119	3839	4470	middle
18	mmu-miR-29b-2-5p_R-2	CTGGTTTCACATGGTGGCTTAGA	up	1.21	0.28	0.01	288.73	349.88	382.84	305.21	351.21	350.93	359.20	276.11	291.26	282.90	297.41	295.98	343	278	404	311	374	234	257	350	236	310	middle
19	hsa-miR-378c_R-2_2ss21AG22GC	ACTGGACTTGGAGTCAGAAGGCT	down	0.88	-0.18	0.01	9067.98	7984.80	7204.73	8129.81	8058.71	8160.63	8370.10	9938.66	8592.68	8967.78	9008.06	8832.73	6455	7405	9270	7232	8715	8423	7582	11095	7148	9251	middle
20	hsa-miR-4508_L+2R-1	AAGCGGGGCTGGGCGCGC	down	0.18	-2.44	0.01	5.96	1.10	0	5.49	0	0	0	7.08	6.80	4.85	6.30	4.77	0	5	0	0	0	6	6	6	5	5	low
21	mmu-miR-200b-5p	CATCTTACTGGGCAGCATTGGA	down	0.90	-0.15	0.01	1819.32	1634.47	1574.88	1743.44	1615.22	1705.02	1533.80	1723.90	1755.48	1916.41	1839.92	1860.88	1411	1588	1858	1511	1597	1461	1549	2371	1460	1949	middle
22	mmu-miR-199b-3p_R-1	ACAGTAGTCTGCACATTGGTT	up	1.39	0.48	0.01	35629.42	49620.83	51071.34	56322.21	55201.89	46249.40	39259.29	28520.00	37443.28	41244.00	31668.53	39271.32	45756.83	51300.83	63499.17	40986.50	40877	24170.67	33039.17	51027.33	25129.33	41131	high
23	mmu-miR-144-5p	GGATATCATCATATACTGTAAGT	down	0.55	-0.87	0.01	2808.58	1534.50	1695.43	1033.11	1410.93	1481.60	2051.47	3636.58	3252.57	1990.78	2802.73	2360.23	1519	941	1623	1313	2136	3082	2870	2463	2224	2472	middle
24	mmu-miR-574-5p	TGAGTGTGTGTGTGTGAGTGTGT	up	1.25	0.32	0.01	214.43	268.31	264.53	306.31	273.84	227.94	268.92	223.01	206.26	217.43	223.06	202.41	237	279	315	202	280	189	182	269	177	212	middle
25	mmu-miR-147-3p_R-1	GTGTGCGGAAATGCTTCTGCT	up	4.07	2.03	0.01	5.37	21.86	20.09	30.74	25.21	16.93	16.33	0	6.80	0	0	20.05	18	28	29	15	17	0	6	0	0	21	middle
26	xtr-miR-200b_R+1_1ss23TA	TAATACTGCCTGGTAATGATGAAT	down	0.92	-0.12	0.01	360.10	330.37	344.89	348.03	310.35	318.21	330.39	366.96	371.72	360.49	356.64	344.68	309	317	357	282	344	311	328	446	283	361	middle
27	mmu-miR-139-5p_R+1	TCTACAGTGCACGTGTCTCCAGT	up	1.11	0.15	0.01	6358.36	7050.53	6982.61	7011.07	7223.28	6967.90	7067.77	6489.69	6517.61	5767.03	6759.83	6257.67	6256	6386	8309	6175	7359	5500	5751	7135	5364	6554	middle
28	mmu-miR-9-3p_L-1	TAAAGCTAGATAACCGAAAGT	down	0.78	-0.37	0.01	532.72	413.13	377.07	380.05	416.56	459.64	432.35	468.24	604.80	497.63	606.80	486.15	337.83	346.17	479.17	407.33	450.17	396.83	533.67	615.67	481.50	509.17	middle
29	mmu-miR-190b-5p_R+2	TGATATGTTTGATATTGGGTTGT	down	0.66	-0.59	0.01	54.84	36.33	23.44	50.50	38.25	40.62	28.81	54.28	48.73	49.30	61.75	60.15	21	46	44	36	30	46	43	61	49	63	middle
30	mmu-miR-615-3p_R-1	TCCGAGCCTGGGTCTCCCTCT	down	0.83	-0.26	0.01	2846.97	2372.79	2269.13	2684.32	2401.97	2440.74	2067.79	3112.69	2577.12	3098.92	2686.79	2759.33	2033	2445	2763	2163	2153	2638	2274	3834	2132	2890	middle
31	pma-miR-27a_R-1_1ss19CA	TTCACAGTGGCTAAGTTCAA	up	1.32	0.40	0.01	53.20	70.15	74.78	71.36	60.85	68.83	74.91	37.76	53.27	58.20	64.27	52.51	67	65	70	61	78	32	47	72	51	55	middle
32	mmu-miR-34c-5p	AGGCAGTGTAGTTAGCTGATTGC	up	1.24	0.31	0.01	2926.15	3632.16	3945.58	3368.30	3488.63	3951.68	3406.63	2869.62	2592.99	2500.80	3400.08	3267.28	3535	3068	4013	3502	3547	2432	2288	3094	2698	3422	middle
33	mmu-miR-155-5p	TTAATGCTAATTGTGATAGGGGT	up	1.36	0.44	0.01	1394.43	1890.04	2300.38	1843.34	1596.09	1705.02	2005.37	1612.98	1109.50	1501.77	1217.37	1530.52	2061	1679	1836	1511	2088	1367	979	1858	966	1603	middle
34	mmu-miR-30c-2-3p	CTGGGAGAAGGCTGTTTACTCT	down	0.89	-0.17	0.01	4034.10	3583.60	3409.83	3577.99	3638.16	3628.95	3663.06	4388.21	3779.55	3791.61	4195.28	4015.83	3055	3259	4185	3216	3814	3719	3335	4691	3329	4206	middle
35	mmu-miR-30e-3p	CTTTCAGTCGGATGTTTACAGC	down	0.92	-0.12	0.02	23711.71	21799.98	19903.69	22027.89	22768.25	22242.00	22058.08	23213.01	24459.44	23659.76	24523.91	22702.43	17832.50	20064	26190.50	19711	22967	19673	21582.50	29272	19460	23777.50	high
36	mmu-miR-142a-3p_L-1	GTAGTGTTTCCTACTTTATGGA	up	1.44	0.53	0.02	5606.56	8096.36	9771.86	6816.74	7499.73	7303.04	9090.42	5130.39	4670.33	5926.25	4544.36	7761.46	8755	6209	8627	6472	9465	4348	4121	7332	3606	8129	middle
37	mmu-miR-141-5p	CATCTTCCAGTGCAGTGTTGGA	down	0.72	-0.47	0.02	74.73	54.13	55.81	60.38	43.47	55.29	55.70	77.88	53.27	81.64	76.87	84.02	50	55	50	49	58	66	47	101	61	88	middle
38	mmu-miR-200c-3p	TAATACTGCCGGGTAATGATGGA	down	0.87	-0.20	0.02	13695.28	11945.85	12554.42	12255.65	10542.39	12011.31	12365.47	13124.50	14391.77	12691.50	15061.54	13207.08	11248	11163	12127	10644.50	12875	11123	12699	15702	11951.50	13832.50	middle
39	mmu-miR-467d-3p	ATATACATACACACACCTACAC	up	1.34	0.42	0.02	12.87	17.22	18.14	17.57	18.04	17.21	15.13	10.03	13.03	15.36	10.40	15.52	16.25	16	20.75	15.25	15.75	8.50	11.50	19	8.25	16.25	middle
40	PC-3p-12776_151	ACTGTGCCTCTCTGTTTTCAGT	up	2.61	1.39	0.02	6.63	17.33	14.51	8.78	26.08	18.05	19.21	10.62	6.80	5.66	10.08	0	13	8	30	16	20	9	6	7	8	0	middle
41	mmu-miR-451a_R+1	AAACCGTTACCATTACTGAGTTT	down	0.55	-0.87	0.02	59802.86	32742.29	33628.38	22237.58	27104.05	32370.57	48370.84	75248.49	77585.70	40112.95	56664.60	49402.56	30129	20255	31178	28687	50364	63773	68460	49628	44964	51742	high
42	mmu-miR-135a-5p	TATGGCTTTTTATTCCTATGTGA	up	2.67	1.42	0.02	5.36	14.33	11.72	11.53	13.04	11.85	23.53	5.90	0	5.66	3.78	11.46	10.50	10.50	15	10.50	24.50	5	0	7	3	12	middle
43	mmu-mir-653-p5	TTGAAACAATCTCTACTGAACC	up	1.46	0.54	0.02	337.76	491.77	504.50	499.54	502.47	468.29	484.05	285.55	316.19	282.09	303.71	501.26	452	455	578	415	504	242	279	349	241	525	middle
44	mmu-miR-124-5p	CGTGTTCACAGCGGACCTTGAT	up	inf	inf	0.02	0	6.62	3.35	7.69	2.61	12.41	7.04	0	0	0	0	0	3	7	3	11	7.33	0	0	0	0	0	middle
45	mmu-miR-1968-5p_R-1	TGCAGCTGTTAAGGATGGTGGAC	down	0.82	-0.29	0.02	189.19	154.70	175.24	135.04	172.13	129.77	161.35	204.13	190.39	203.68	170.13	177.59	157	123	198	115	168	173	168	252	135	186	middle
46	bta-miR-2478_L+2	TCGTATCCCACTTCTGACACCA	up	1.41	0.49	0.02	97.32	137.12	148.45	122.96	140.83	152.33	121.01	69.62	70.26	109.93	122.24	114.57	133	112	162	135	126	59	62	136	97	120	middle
47	mmu-miR-574-3p	CACGCTCATGCACACACCCACA	up	1.09	0.12	0.02	867.80	943.46	973.28	994.68	950.18	904.98	894.16	834.22	874.91	871.32	826.71	931.87	872	906	1093	802	931	707	772	1078	656	976	middle
48	mmu-miR-9-5p	TCTTTGGTTATCTAGCTGTATGA	down	0.81	-0.30	0.02	2158.69	1753.46	1540.28	1554.23	1998.02	1954.02	1720.76	2072.77	2138.16	1938.78	2565.81	2077.93	1380	1415.67	2298.33	1731.67	1791.67	1756.67	1886.67	2398.67	2036	2176.33	middle
49	mmu-miR-5621-3p	TGGGCCCTCCAGACCTCATGC	up	2.98	1.57	0.02	3.91	11.64	8.93	5.49	11.30	18.05	14.41	7.08	6.80	5.66	0	0	8	5	13	16	15	6	6	7	0	0	middle
50	mmu-miR-142a-5p	CATAAAGTAGAAAGCACTACT	up	1.39	0.48	0.02	15352.16	21342.98	23845.36	21664.49	21402.53	18459.02	21343.52	14622.44	10748.78	19721.45	12560.00	19108.14	21364	19733	24619.50	16358.50	22223	12392.50	9484.50	24399.50	9966.50	20013	high
51	mmu-miR-339-5p_R-2	TCCCTGTCCTCCAGGAGCTCA	up	1.13	0.18	0.02	6732.81	7626.10	7863.25	6893.60	7793.57	8394.21	7185.90	6316.23	6710.27	7024.70	6864.43	6748.43	7045	6279	8965	7439	7482	5353	5921	8691	5447	7068	middle
52	PC-3p-5037_668	CAGTCGGTCCTGAGAGATG	up	1.25	0.32	0.02	41.57	51.77	49.11	54.89	44.34	51.91	58.59	35.40	48.73	34.76	44.11	44.87	44	50	51	46	61	30	43	43	35	47	middle
53	mmu-miR-378a-5p	CTCCTGACTCCAGGTCCTGTGT	down	0.92	-0.13	0.02	3309.30	3029.24	3003.55	3003.80	2774.91	3220.47	3143.47	3497.35	3367.03	3368.07	3183.32	3130.74	2691	2736	3192	2854	3273	2964	2971	4167	2526	3279	middle
54	mmu-miR-7667-5p	GAGCCATCTCTCTAGCCCCTGA	up	2.39	1.26	0.03	3.45	8.24	7.81	6.59	7.82	11.28	7.68	0	6.80	5.66	0	4.77	7	6	9	10	8	0	6	7	0	5	middle
55	mmu-miR-214-3p	ACAGCAGGCACAGACAGGCAGT	up	1.45	0.54	0.03	3250.49	4721.29	4647.63	6274.39	4783.07	4031.79	3869.55	2536.88	3387.43	4287.89	2565.81	3474.47	4164	5715	5502	3573	4029	2150	2989	5305	2036	3639	middle
56	mmu-miR-30d-5p_R-2	TGTAAACATCCCCGACTGGA	down	0.92	-0.11	0.03	330754.51	305807.78	287849.78	309716.64	299268.13	314131.77	318072.56	331586.92	336979.86	314761.97	354185.90	316257.87	257896	282104	344250.50	278385.50	331179	281019.50	297344	389425.50	281050.50	331234.17	high
57	mmu-miR-130a-5p	GCTCTTTTCACATTGTGCTACT	up	1.21	0.28	0.03	54.40	65.87	60.27	66.97	63.46	73.35	65.31	51.92	51.00	67.09	46.63	55.38	54	61	73	65	68	44	45	83	37	58	middle
58	mmu-miR-29a-5p_R+1	ACTGATTTCTTTTGGTGTTCAGA	up	1.14	0.19	0.03	641.01	731.26	692.01	703.74	709.38	742.49	808.68	619.47	602.92	577.91	694.38	710.36	620	641	816	658	842	525	532	715	551	744	middle
59	mmu-miR-214-5p	TGCCTGTCTACACTTGCTGTGC	up	1.34	0.43	0.03	491.98	661.66	661.88	782.79	664.17	644.32	555.13	352.80	570.05	637.73	413.35	485.99	593	713	764	571	578	299	503	789	328	509	middle
60	mmu-miR-29c-3p_R-1	TAGCACCATTTGAAATCGGTT	up	1.15	0.20	0.03	18149.44	20916.40	21512.24	18801.21	19635.90	22781.29	21851.35	16929.52	20939.13	16676.21	18142.15	18060.18	19273.67	17125	22587.33	20188.92	22751.75	14347.75	18476.25	20631.92	14396	18915.42	high
61	mmu-miR-15a-3p_1ss22AT	CAGGCCATACTGTGCTGCCTCT	up	1.14	0.19	0.03	243.56	277.96	279.04	307.41	266.02	274.20	263.16	223.01	254.99	231.17	278.51	230.10	250	280	306	243	274	189	225	286	221	241	middle
62	mmu-miR-676-3p	CCGTCCTGAGGTTGTTGAGCT	up	1.14	0.18	0.03	748.09	850.39	842.69	914.53	869.33	828.25	797.15	657.23	839.78	796.96	720.85	725.64	755	833	1000	734	830	557	741	986	572	760	middle
63	bta-miR-339b_R+3	TCCCTGTCCTCCAGGAGCTCATT	up	1.12	0.16	0.03	423.49	474.73	476.59	417.19	497.26	490.86	491.74	435.40	446.52	413.84	443.60	378.10	427	380	572	435	512	369	394	512	352	396	middle
64	mmu-miR-23a-3p	ATCACATTGCCAGGGATTTCC	up	1.09	0.13	0.03	47288.41	51714.59	48176.80	51149.73	51774.40	52209.64	55262.37	49509.81	46146.83	43511.34	46721.45	50552.60	43163.50	46589.50	59556.50	46268.50	57539.50	41959.50	40719	53832.50	37074	52946.50	high
65	mmu-miR-153-3p	TTGCATAGTCACAAAAGTGATC	up	1.61	0.68	0.03	13.72	22.05	22.32	28.54	24.34	22.57	12.49	12.98	11.33	12.93	15.12	16.23	20	26	28	20	13	11	10	16	12	17	middle
66	mmu-miR-16-2-3p	ACCAATATTATTGTGCTGCTTT	down	0.87	-0.19	0.03	383.30	335.15	370.56	298.62	328.61	328.37	349.59	387.02	402.32	341.90	364.20	421.06	332	272	378	291	364	328	355	423	289	441	middle
67	mmu-miR-652-3p_R+1	AATGGCGCCACTAGGGTTGTGT	down	0.94	-0.08	0.03	7606.12	7174.39	7240.44	7152.70	7118.96	7132.65	7227.20	7520.96	8061.16	7634.94	7595.36	7218.19	6487	6515	8189	6321	7525	6374	7113	9446	6027	7560	middle
68	mmu-miR-146b-3p	GCCCTAGGGACTCAGTTCTGGT	up	3.09	1.63	0.03	2.23	6.89	7.81	10.98	5.22	5.64	4.80	0	0	4.85	6.30	0	7	10	6	5	5	0	0	6	5	0	middle
69	mmu-miR-15b-3p_R-1	CGAATCATTATTTGCTGCTCT	up	1.21	0.28	0.03	366.59	444.76	425.25	454.52	488.56	391.56	463.89	400.00	349.06	441.32	342.78	299.80	381	414	562	347	483	339	308	546	272	314	middle
70	mmu-miR-503-3p	GAGTATTGTTTCCACTGCCTGG	down	0.78	-0.36	0.03	796.34	621.56	646.25	562.12	643.31	625.14	631.00	765.78	876.04	704.01	970.37	665.49	579	512	740	554	657	649	773	871	770	697	middle
71	mmu-miR-455-5p_R+1	TATGTGCCTTTGGACTACATCGT	down	0.88	-0.18	0.03	3006.13	2652.93	2717.82	2768.86	2782.73	2658.52	2336.71	2764.61	3143.77	3363.22	2898.51	2860.54	2435	2522	3201	2356	2433	2343	2774	4161	2300	2996	middle
72	rno-miR-203b-3p_1ss10TC	TTGAACTGTCAAGAACCACTGG	up	1.34	0.42	0.03	419.03	561.54	507.85	486.36	512.04	742.49	558.97	448.38	447.65	414.64	439.82	344.68	455	443	589	658	582	380	395	513	349	361	middle
73	mmu-miR-137-3p	TTATTGCTTAAGAATACGCGTAG	up	2.59	1.37	0.03	9.40	24.36	23.44	32.94	24.34	18.05	23.05	0	14.73	6.47	0	25.78	21	30	28	16	24	0	13	8	0	27	middle
74	mmu-miR-34a-5p	TGGCAGTGTCTTAGCTGGTTGT	up	1.30	0.38	0.04	17249.57	22379.13	24741.62	21087.00	22456.60	22919.05	20691.39	19010.06	13961.12	14809.98	15388.57	23078.14	22167	19207	25832	20311	21544	16111	12319	18323	12211	24171	high
75	mmu-miR-350-3p	TTCACAAAGCCCATACACTTTC	up	1.11	0.15	0.04	791.28	880.09	901.85	917.83	902.37	784.24	894.16	723.30	776.31	859.19	757.39	840.21	808	836	1038	695	931	613	685	1063	601	880	middle
76	mdo-miR-219-5p_R+3	TGATTGTCCAAACGCAATTCTCGT	up	1.36	0.44	0.04	6.90	9.35	11.16	7.69	9.13	10.16	8.64	5.31	9.07	5.25	8.19	6.68	10	7	10.50	9	9	4.50	8	6.50	6.50	7	middle
77	mmu-miR-488-3p_R+1	TTGAAAGGCTGTTTCTTGGTCT	up	1.65	0.72	0.04	14.88	24.49	27.90	28.54	19.13	18.05	28.81	17.70	5.67	23.44	11.34	16.23	25	26	22	16	30	15	5	29	9	17	middle
78	mmu-miR-467e-5p	ATAAGTGTGAGCATGTATATGT	up	1.41	0.49	0.04	80.03	112.68	103.80	111.98	118.23	134.28	95.08	47.20	87.26	98.61	63.01	104.07	93	102	136	119	99	40	77	122	50	109	middle
79	mmu-miR-27a-3p	TTCACAGTGGCTAAGTTCCGC	up	1.05	0.07	0.04	81099.97	85201.42	84400.23	86740.29	86473.37	87854.84	80538.35	79237.87	80849.60	78930.65	84652.23	81829.49	75617.50	79007	99471	77857.50	83857	67154	71340	97653.50	67172.50	85704.50	high
80	mmu-miR-30c-5p_R+1	TGTAAACATCCTACACTCTCAGCT	down	0.92	-0.12	0.04	576083.50	530327.37	514997.36	505210.65	533369.65	528127.51	569931.66	590172.75	607291.48	535195.84	600982.45	546774.97	461406.50	460168.83	613539.33	468029.83	593416.17	500170.67	535861.33	662147.67	476886.33	572667.33	high
81	mmu-miR-183-3p_L-1R+1	TGAATTACCGAAGGGCCATAAT	down	0.82	-0.28	0.04	37.62	30.95	32.37	35.13	23.47	34.98	28.81	34.22	43.07	37.99	36.55	36.28	29	32	27	31	30	29	38	47	29	38	middle
82	mmu-miR-409-5p	AGGTTACCCGAGCAACTTTGCAT	down	0.61	-0.71	0.04	41.25	25.17	33.48	32.94	25.21	16.93	17.29	60.18	41.93	27.48	36.55	40.10	30	30	29	15	18	51	37	34	29	42	middle
83	mmu-miR-380-3p_R-1	TATGTAGTATGGTCCACATCT	up	4.43	2.15	0.04	1.94	8.59	5.58	15.37	10.43	6.77	4.80	0	0	9.70	0	0	5	14	12	6	5	0	0	12	0	0	middle
84	xtr-miR-187_R+1	TCGTGTCTTGTGTTGCAGCCAT	up	1.90	0.93	0.04	7.02	13.34	14.51	8.78	8.69	20.31	14.41	5.90	9.07	4.04	11.34	4.77	13	8	10	18	15	5	8	5	9	5	middle
85	mmu-miR-150-5p	TCTCCCAACCCTTGTACCAGTG	up	1.30	0.37	0.04	2192.77	2842.73	3062.71	2376.91	2477.60	2676.58	3619.84	2074.34	2158.94	2322.98	2128.51	2279.08	2744	2165	2850	2372	3769	1758	1905	2874	1689	2387	middle
86	mmu-miR-542-5p	CTCGGGGATCATCATGTCACGA	down	0.71	-0.49	0.05	54.13	38.52	27.90	39.52	32.17	44.01	48.98	40.12	65.73	49.30	66.79	48.69	25	36	37	39	51	34	58	61	53	51	middle
87	mmu-miR-33-5p_R-1	GTGCATTGTAGTTGCATTGC	up	1.18	0.24	0.05	732.32	867.57	924.17	758.64	858.90	1000.90	795.23	637.17	794.44	652.28	805.28	772.42	828	691	988	887	828	540	701	807	639	809	middle
88	mmu-miR-130b-5p	ACTCTTTCCCTGTTGCACTACT	up	1.47	0.56	0.05	28.50	41.97	43.53	47.21	55.64	32.72	30.73	24.78	19.27	36.37	27.72	34.37	39	43	64	29	32	21	17	45	22	36	middle
89	PC-3p-6005_506	TCCGGTGTCCTTTACTCCAGT	up	1.27	0.34	0.05	27.71	35.05	36.83	29.64	36.51	33.85	38.42	21.24	36.27	27.48	23.94	29.60	33	27	42	30	40	18	32	34	19	31	middle
90	mmu-miR-223-3p_R+1	TGTCAGTTTGTCAAATACCCCAT	up	1.45	0.54	0.05	1423.62	2063.49	2077.15	2475.72	2326.33	1721.95	1716.28	2089.68	839.78	1660.19	1076.23	1452.23	1861	2255	2676	1526	1787	1771	741	2054	854	1521	middle
91	mmu-miR-148a-5p	AAAGTTCTGAGACACTCCGACT	up	1.53	0.61	0.05	38.26	58.40	66.97	66.97	57.38	69.96	30.73	36.58	26.07	41.22	37.81	49.65	60	61	66	62	32	31	23	51	30	52	middle

document location: Final_Report/3_Summary/3_DifferentiallymiRNAs/Table8.*_*vs*.xlsx

4.3.2 Heatmap of differentially expressed miRNAs

Heatmap is a graphical representation of data where the individual z values (repeated) or Log10 (non-repeated) contained in a matrix are represented as color scheme. Calculation formula of z value is shown below. Sample-i means expression level (the value after normalization).

document location: Final_Report/3_Summary/3_DifferentiallymiRNAs/Fig6.1_heatmap_of_differentially_expressed_miRNAs.pdf

4.3.3 Volcano of differentially expressed miRNAs

document location: Final_Report/3_Summary/3_DifferentiallymiRNAs/Fig6.2_volcano_of_differentially_expressed_miRNAs.pdf

LC Sciences

5. Target prediction and enrichment analysis

5.1 Target prediction of differentially expressed miRNAs

Animal: To predict the genes targeted by most aboundant miRNAs, two computational target prediction algorithms TargetScan (http://www.targetscan.org/) and Miranda 3.3a (http://www.microrna.org/) were used to identify miRNA binding sites. Finally, the data predicted by both algorithms were combined and the overlaps were calculated. The GO terms and KEGG pathways of these most aboundant miRNAs, miRNA targets were also annotated.

Plant: To predict the genes targeted by most aboundant miRNAs, computational target prediction algorithms TargetFinder (https://github.com/carringtonlab/TargetFinder/) were used to identify miRNA binding sites. The GO terms and KEGG pathways of most aboundant miRNA targets were also annotated.

Transcript ID	Species ID	Gene ID	Symbol	Gene Annoation	miRNA ID	TargetScan	miRanda	Total	GO Term	KEGG pathways
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	PC-3p-10415_211	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	efu-miR-9226_L-4_1ss22GT	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mdo-miR-26-5p_L+1R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-101a-3p_L+1R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-101a-5p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-101c_L+2R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-10b-3p_L+1R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-124-3p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-139-5p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-143-3p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-148a-5p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-153-3p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-192-3p_R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-195a-5p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-200b-3p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-200c-3p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-29a-5p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-3058-3p_R+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-3098-5p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-33-5p_R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-338-5p_R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-345-5p_L+1R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-378a-5p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-429-3p	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-5113_L+1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	mmu-miR-615-3p_R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	pma-miR-15a_R+1_1ss10GA	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	pma-miR-200b-3p_R-1	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	rno-miR-101b-3p_L+1R-1_1ss17GA	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000001	mmu	ENSMUSG00000000001	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773]	xtr-miR-200b_R+1_1ss23TA	1	1	2	GO:0000166(nucleotide binding);GO:0001664(G-protein coupled receptor binding);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0019001(guanyl nucleotide binding);GO:0019003(GDP binding);GO:0019904(protein domain specific binding);GO:0031683(G-protein beta/gamma-subunit complex binding);GO:0031821(G-protein coupled serotonin receptor binding);GO:0032794(GTPase activating protein binding);GO:0046872(metal ion binding);GO:0006906(vesicle fusion);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007193(adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway);GO:0007212(dopamine receptor signaling pathway);GO:0046039(GTP metabolic process);GO:0051301(cell division);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005794(Golgi apparatus);GO:0005813(centrosome);GO:0005815(microtubule organizing center);GO:0005834(heterotrimeric G-protein complex);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0016020(membrane);GO:0030496(midbody);GO:0042588(zymogen granule);GO:0045121(membrane raft);GO:0070062(extracellular exosome)	ko04015(Rap1 signaling pathway);ko04022(cGMP - PKG signaling pathway);ko04024(cAMP signaling pathway);ko04062(Chemokine signaling pathway);ko04071(Sphingolipid signaling pathway);ko04261(Adrenergic signaling in cardiomyocytes);ko04360(Axon guidance);ko04530(Tight junction);ko04540(Gap junction);ko04611(Platelet activation);ko04670(Leukocyte transendothelial migration);ko04713(Circadian entrainment);ko04723(Retrograde endocannabinoid signaling);ko04724(Glutamatergic synapse);ko04725(Cholinergic synapse);ko04726(Serotonergic synapse);ko04727(GABAergic synapse);ko04728(Dopaminergic synapse);ko04730(Long-term depression);ko04914(Progesterone-mediated oocyte maturation);ko04915(Estrogen signaling pathway);ko04916(Melanogenesis);ko04921(Oxytocin signaling pathway);ko04923(Regulation of lipolysis in adipocyte);ko04971(Gastric acid secretion);ko05012(Parkinson's disease);ko05030(Cocaine addiction);ko05032(Morphine addiction);ko05034(Alcoholism);ko05133(Pertussis);ko05142(Chagas disease (American trypanosomiasis));ko05145(Toxoplasmosis);ko05200(Pathways in cancer)
ENSMUST00000000003	mmu	ENSMUSG00000000003	Pbsn	probasin [Source:MGI Symbol;Acc:MGI:1860484]	mmu-miR-155-5p	1	1	2	GO:0005215(transporter activity);GO:0005549(odorant binding);GO:0006810(transport);GO:0005576(extracellular region)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	PC-3p-10415_211	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	hsa-miR-378c_R-2_2ss21AG22GC	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	hsa-miR-4286_R+1	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	hsa-mir-6087-p3	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-130b-5p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-141-5p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-148a-5p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-15a-3p_1ss22AT	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-190a-5p_R+1	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-190b-5p_R+2	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-195a-5p_R+1	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-3058-5p_R-3	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-30b-3p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-30c-2-3p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-3473a_1ss18AC	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-350-3p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-365-2-5p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-378a-3p_R+1	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-378d_1ss6CA	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-6516-5p_R+3	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-7085-3p	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-miR-9769-3p_1ss22CT	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-mir-3473f-p3_1ss18GC	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	mmu-mir-690-p3_1ss18TC	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	pma-miR-15a_R+1_1ss10GA	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000010	mmu	ENSMUSG00000020875	Hoxb9	homeobox B9 [Source:MGI Symbol;Acc:MGI:96190]	rno-miR-181a-2-3p_R+3_1ss7AG	1	1	2	GO:0003677(DNA binding);GO:0043565(sequence-specific DNA binding);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organism development);GO:0009952(anterior/posterior pattern specification);GO:0030879(mammary gland development);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048706(embryonic skeletal system development);GO:0060070(canonical Wnt signaling pathway);GO:0060326(cell chemotaxis);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion)
ENSMUST00000000028	mmu	ENSMUSG00000000028	Cdc45	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]	mmu-miR-200a-5p	1	1	2	GO:0006270(DNA replication initiation);GO:0051301(cell division);GO:0005634(nucleus);GO:0005813(centrosome);GO:0003682(chromatin binding);GO:0003688(DNA replication origin binding);GO:0003697(single-stranded DNA binding);GO:0043138(3'-5' DNA helicase activity);GO:0000727(double-strand break repair via break-induced replication);GO:0006260(DNA replication);GO:0006267(pre-replicative complex assembly involved in nuclear cell cycle DNA replication);GO:0007049(cell cycle);GO:0031938(regulation of chromatin silencing at telomere);GO:0032508(DNA duplex unwinding);GO:1900087(positive regulation of G1/S transition of mitotic cell cycle);GO:1902977(mitotic DNA replication preinitiation complex assembly);GO:0005656(nuclear pre-replicative complex);GO:0031261(DNA replication preinitiation complex);GO:0031298(replication fork protection complex)	ko04110(Cell cycle)
ENSMUST00000000028	mmu	ENSMUSG00000000028	Cdc45	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]	mmu-miR-200b-5p	1	1	2	GO:0006270(DNA replication initiation);GO:0051301(cell division);GO:0005634(nucleus);GO:0005813(centrosome);GO:0003682(chromatin binding);GO:0003688(DNA replication origin binding);GO:0003697(single-stranded DNA binding);GO:0043138(3'-5' DNA helicase activity);GO:0000727(double-strand break repair via break-induced replication);GO:0006260(DNA replication);GO:0006267(pre-replicative complex assembly involved in nuclear cell cycle DNA replication);GO:0007049(cell cycle);GO:0031938(regulation of chromatin silencing at telomere);GO:0032508(DNA duplex unwinding);GO:1900087(positive regulation of G1/S transition of mitotic cell cycle);GO:1902977(mitotic DNA replication preinitiation complex assembly);GO:0005656(nuclear pre-replicative complex);GO:0031261(DNA replication preinitiation complex);GO:0031298(replication fork protection complex)	ko04110(Cell cycle)
ENSMUST00000000028	mmu	ENSMUSG00000000028	Cdc45	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]	mmu-miR-23a-3p	1	1	2	GO:0006270(DNA replication initiation);GO:0051301(cell division);GO:0005634(nucleus);GO:0005813(centrosome);GO:0003682(chromatin binding);GO:0003688(DNA replication origin binding);GO:0003697(single-stranded DNA binding);GO:0043138(3'-5' DNA helicase activity);GO:0000727(double-strand break repair via break-induced replication);GO:0006260(DNA replication);GO:0006267(pre-replicative complex assembly involved in nuclear cell cycle DNA replication);GO:0007049(cell cycle);GO:0031938(regulation of chromatin silencing at telomere);GO:0032508(DNA duplex unwinding);GO:1900087(positive regulation of G1/S transition of mitotic cell cycle);GO:1902977(mitotic DNA replication preinitiation complex assembly);GO:0005656(nuclear pre-replicative complex);GO:0031261(DNA replication preinitiation complex);GO:0031298(replication fork protection complex)	ko04110(Cell cycle)
ENSMUST00000000028	mmu	ENSMUSG00000000028	Cdc45	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073]	mmu-miR-23b-3p	1	1	2	GO:0006270(DNA replication initiation);GO:0051301(cell division);GO:0005634(nucleus);GO:0005813(centrosome);GO:0003682(chromatin binding);GO:0003688(DNA replication origin binding);GO:0003697(single-stranded DNA binding);GO:0043138(3'-5' DNA helicase activity);GO:0000727(double-strand break repair via break-induced replication);GO:0006260(DNA replication);GO:0006267(pre-replicative complex assembly involved in nuclear cell cycle DNA replication);GO:0007049(cell cycle);GO:0031938(regulation of chromatin silencing at telomere);GO:0032508(DNA duplex unwinding);GO:1900087(positive regulation of G1/S transition of mitotic cell cycle);GO:1902977(mitotic DNA replication preinitiation complex assembly);GO:0005656(nuclear pre-replicative complex);GO:0031261(DNA replication preinitiation complex);GO:0031298(replication fork protection complex)	ko04110(Cell cycle)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	PC-3p-12776_151	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	PC-3p-5198_638	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-101a-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-1198-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-148a-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-183-3p_L-1R+1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-192-3p_R-1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-195a-5p_R+1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-22-5p_R-1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-3058-5p_R-3	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-30b-3p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-34a-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-34b-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-34c-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-361-3p_R-3	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-3968_L-3_1ss14AT	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-450a-5p	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-674-5p_R-1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000033	mmu	ENSMUSG00000048583	Igf2	insulin-like growth factor 2 [Source:MGI Symbol;Acc:MGI:96434]	mmu-miR-744-5p_R-1	1	1	2	GO:0005158(insulin receptor binding);GO:0005159(insulin-like growth factor receptor binding);GO:0005179(hormone activity);GO:0005515(protein binding);GO:0008083(growth factor activity);GO:0030546(receptor activator activity);GO:0043539(protein serine/threonine kinase activator activity);GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0001934(positive regulation of protein phosphorylation);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0009887(animal organ morphogenesis);GO:0031017(exocrine pancreas development);GO:0038028(insulin receptor signaling pathway via phosphatidylinositol 3-kinase);GO:0040018(positive regulation of multicellular organism growth);GO:0042104(positive regulation of activated T cell proliferation);GO:0043085(positive regulation of catalytic activity);GO:0043410(positive regulation of MAPK cascade);GO:0045725(positive regulation of glycogen biosynthetic process);GO:0045840(positive regulation of mitotic nuclear division);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051146(striated muscle cell differentiation);GO:0051781(positive regulation of cell division);GO:0051897(positive regulation of protein kinase B signaling);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:2000273(positive regulation of receptor activity);GO:2000467(positive regulation of glycogen (starch) synthase activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0070062(extracellular exosome)	ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-101a-3p_L+1R-1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-101a-5p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-101c_L+2R+1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-144-3p_R-1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-152-5p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-183-3p_L-1R+1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-192-3p_R-1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-195a-5p_R+1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-199b-3p_R-1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-21a-5p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-23a-3p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-23b-3p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-27a-3p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-29b-3p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-29c-3p_R-1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-30a-5p_R+2	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-30c-5p_R+1	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-30d-5p_R-2	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)
ENSMUST00000000058	mmu	ENSMUSG00000000058	Cav2	caveolin 2 [Source:MGI Symbol;Acc:MGI:107571]	mmu-miR-30e-3p	1	1	2	GO:0005925(focal adhesion);GO:0019901(protein kinase binding);GO:0030674(protein binding, bridging);GO:0031748(D1 dopamine receptor binding);GO:0032947(protein complex scaffold);GO:0042803(protein homodimerization activity);GO:0046982(protein heterodimerization activity);GO:0097110(scaffold protein binding);GO:0001937(negative regulation of endothelial cell proliferation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0006897(endocytosis);GO:0006906(vesicle fusion);GO:0007005(mitochondrion organization);GO:0007029(endoplasmic reticulum organization);GO:0007088(regulation of mitotic nuclear division);GO:0008285(negative regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0016050(vesicle organization);GO:0019065(receptor-mediated endocytosis of virus by host cell);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0044791(positive regulation by host of viral release from host cell);GO:0044794(positive regulation by host of viral process);GO:0048278(vesicle docking);GO:0048741(skeletal muscle fiber development);GO:0051259(protein oligomerization);GO:0060161(positive regulation of dopamine receptor signaling pathway);GO:0070836(caveola assembly);GO:0000139(Golgi membrane);GO:0002080(acrosomal membrane);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005901(caveola);GO:0016020(membrane);GO:0030133(transport vesicle);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031410(cytoplasmic vesicle);GO:0043234(protein complex);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0016021(integral component of membrane)	ko04144(Endocytosis);ko04510(Focal adhesion);ko05100(Bacterial invasion of epithelial cells);ko05205(Proteoglycans in cancer)

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichment/2_Target_predict_annotation.xlsx

5.2 GO enrichment analysis of target genes

Gene ontology (GO) (http://www.geneontology.org) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis.

GO is part of a larger classification effort, the Open Biomedical Ontologies (OBO).

Although gene nomenclature itself aims to maintain and develop controlled vocabulary of gene and gene products, the Gene Ontology extends the effort by using markup language to make the data (not only of the genes and their products but also of all their attributes) machine readable, and to do so in a way that is unified across all species (whereas gene nomenclature conventions vary by biologic taxon).

Significant GO terms were calculated by Hypergeometric equation as shown below. TB gene number=number of total genes; TS gene number=number of target genes in total genes; B gene number=total number of gene in all GO terms; S gene number=number of target genes in this GO term. Those GO terms with p value<0.05 were defined as significant GO terms.

Significant GO terms:

GO Id	Function	GO_term	S gene number	TS gene number	B gene number	TB gene number	Pvalue of Fisher's Exact Test
GO:0005737	cellular_component	cytoplasm	5396	19034	5699	21754	2.94e-94
GO:0005515	molecular_function	protein binding	3837	19034	4030	21754	7.28e-73
GO:0005829	cellular_component	cytosol	2891	19034	3033	21754	9.64e-55
GO:0005634	cellular_component	nucleus	5320	19034	5741	21754	1.11e-47
GO:0006351	biological_process	transcription, DNA-templated	1674	19034	1745	21754	2.67e-36
GO:0005654	cellular_component	nucleoplasm	1968	19034	2072	21754	3.08e-33
GO:0016740	molecular_function	transferase activity	1601	19034	1676	21754	3.19e-31
GO:0046872	molecular_function	metal ion binding	3160	19034	3406	21754	3.33e-27
GO:0005794	cellular_component	Golgi apparatus	1092	19034	1132	21754	4.15e-27
GO:0045944	biological_process	positive regulation of transcription from RNA polymerase II promoter	966	19034	997	21754	1.22e-26
GO:0006810	biological_process	transport	1677	19034	1770	21754	1.84e-26
GO:0006355	biological_process	regulation of transcription, DNA-templated	2099	19034	2236	21754	1.20e-25
GO:0005524	molecular_function	ATP binding	1405	19034	1478	21754	3.25e-24
GO:0000166	molecular_function	nucleotide binding	1852	19034	1973	21754	1.47e-22
GO:0005783	cellular_component	endoplasmic reticulum	1217	19034	1279	21754	1.44e-21
GO:0016310	biological_process	phosphorylation	648	19034	664	21754	2.39e-21
GO:0016301	molecular_function	kinase activity	645	19034	661	21754	3.35e-21
GO:0006468	biological_process	protein phosphorylation	601	19034	617	21754	4.63e-19
GO:0000139	cellular_component	Golgi membrane	403	19034	408	21754	8.19e-18
GO:0043231	cellular_component	intracellular membrane-bounded organelle	700	19034	728	21754	2.01e-16
GO:0005768	cellular_component	endosome	500	19034	513	21754	2.94e-16
GO:0008270	molecular_function	zinc ion binding	974	19034	1027	21754	4.92e-16
GO:0007049	biological_process	cell cycle	549	19034	566	21754	5.99e-16
GO:0045893	biological_process	positive regulation of transcription, DNA-templated	530	19034	546	21754	1.07e-15
GO:0007275	biological_process	multicellular organismal development	897	19034	944	21754	1.40e-15
GO:0000122	biological_process	negative regulation of transcription from RNA polymerase II promoter	692	19034	721	21754	1.42e-15
GO:0004672	molecular_function	protein kinase activity	527	19034	543	21754	1.48e-15
GO:0005856	cellular_component	cytoskeleton	990	19034	1046	21754	1.88e-15
GO:0042803	molecular_function	protein homodimerization activity	674	19034	702	21754	2.54e-15
GO:0005886	cellular_component	plasma membrane	4215	19034	4644	21754	3.22e-15
GO:0006915	biological_process	apoptotic process	515	19034	531	21754	5.33e-15
GO:0030054	cellular_component	cell junction	665	19034	693	21754	6.05e-15
GO:0015031	biological_process	protein transport	550	19034	569	21754	8.55e-15
GO:0005730	cellular_component	nucleolus	742	19034	777	21754	9.37e-15
GO:0048471	cellular_component	perinuclear region of cytoplasm	568	19034	589	21754	1.83e-14
GO:0004674	molecular_function	protein serine/threonine kinase activity	392	19034	401	21754	7.59e-14
GO:0016787	molecular_function	hydrolase activity	1479	19034	1592	21754	2.94e-13
GO:0016567	biological_process	protein ubiquitination	485	19034	502	21754	4.79e-13
GO:0005789	cellular_component	endoplasmic reticulum membrane	702	19034	738	21754	9.18e-13
GO:0042802	molecular_function	identical protein binding	748	19034	789	21754	1.88e-12
GO:0043565	molecular_function	sequence-specific DNA binding	557	19034	581	21754	1.93e-12
GO:0003677	molecular_function	DNA binding	1637	19034	1771	21754	2.30e-12
GO:0005739	cellular_component	mitochondrion	1496	19034	1616	21754	5.85e-12
GO:0000978	molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding	350	19034	359	21754	8.44e-12
GO:0007399	biological_process	nervous system development	359	19034	369	21754	1.48e-11
GO:0070062	cellular_component	extracellular vesicular exosome	2407	19034	2635	21754	1.83e-11
GO:0006811	biological_process	ion transport	572	19034	600	21754	3.40e-11
GO:0007155	biological_process	cell adhesion	489	19034	510	21754	4.17e-11
GO:0051301	biological_process	cell division	335	19034	344	21754	4.40e-11
GO:0000977	molecular_function	RNA polymerase II regulatory region sequence-specific DNA binding	199	19034	200	21754	6.55e-11
GO:0019901	molecular_function	protein kinase binding	370	19034	382	21754	8.30e-11
GO:0045202	cellular_component	synapse	431	19034	448	21754	1.06e-10
GO:0006366	biological_process	transcription from RNA polymerase II promoter	414	19034	430	21754	1.69e-10
GO:0004842	molecular_function	ubiquitin-protein transferase activity	330	19034	340	21754	3.36e-10
GO:0030154	biological_process	cell differentiation	684	19034	725	21754	3.50e-10
GO:0055085	biological_process	transmembrane transport	465	19034	486	21754	3.94e-10
GO:0042995	cellular_component	cell projection	637	19034	674	21754	5.39e-10
GO:0035556	biological_process	intracellular signal transduction	397	19034	413	21754	8.92e-10
GO:0008134	molecular_function	transcription factor binding	306	19034	315	21754	1.01e-09
GO:0031410	cellular_component	cytoplasmic vesicle	576	19034	608	21754	1.04e-09
GO:0043005	cellular_component	neuron projection	301	19034	310	21754	1.73e-09
GO:0003700	molecular_function	sequence-specific DNA binding transcription factor activity	806	19034	862	21754	2.79e-09
GO:0016569	biological_process	covalent chromatin modification	238	19034	243	21754	3.28e-09
GO:0005096	molecular_function	GTPase activator activity	220	19034	224	21754	4.35e-09
GO:0003824	molecular_function	catalytic activity	483	19034	508	21754	4.49e-09
GO:0016020	cellular_component	membrane	8036	19034	9029	21754	7.29e-09
GO:0007067	biological_process	mitotic nuclear division	245	19034	251	21754	8.00e-09
GO:0045892	biological_process	negative regulation of transcription, DNA-templated	511	19034	540	21754	1.60e-08
GO:0006974	biological_process	cellular response to DNA damage stimulus	390	19034	408	21754	1.60e-08
GO:0016055	biological_process	Wnt signaling pathway	184	19034	187	21754	4.56e-08
GO:0006629	biological_process	lipid metabolic process	432	19034	455	21754	5.43e-08
GO:0001077	molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	255	19034	263	21754	5.46e-08
GO:0001701	biological_process	in utero embryonic development	241	19034	248	21754	5.77e-08
GO:0043547	biological_process	positive regulation of GTPase activity	420	19034	442	21754	5.97e-08
GO:0006357	biological_process	regulation of transcription from RNA polymerase II promoter	373	19034	391	21754	7.45e-08
GO:0046777	biological_process	protein autophosphorylation	159	19034	161	21754	1.22e-07
GO:0044212	molecular_function	transcription regulatory region DNA binding	220	19034	226	21754	1.26e-07
GO:0014069	cellular_component	postsynaptic density	190	19034	194	21754	1.41e-07
GO:0046983	molecular_function	protein dimerization activity	188	19034	192	21754	1.78e-07
GO:0030182	biological_process	neuron differentiation	115	19034	115	21754	2.04e-07
GO:0031625	molecular_function	ubiquitin protein ligase binding	280	19034	291	21754	2.07e-07
GO:0009986	cellular_component	cell surface	499	19034	530	21754	2.14e-07
GO:0043065	biological_process	positive regulation of apoptotic process	265	19034	275	21754	2.70e-07
GO:0001525	biological_process	angiogenesis	212	19034	218	21754	2.99e-07
GO:0016323	cellular_component	basolateral plasma membrane	168	19034	171	21754	3.03e-07
GO:0008283	biological_process	cell proliferation	195	19034	200	21754	4.18e-07
GO:0019904	molecular_function	protein domain specific binding	222	19034	229	21754	4.33e-07
GO:0031965	cellular_component	nuclear membrane	222	19034	229	21754	4.33e-07
GO:0032403	molecular_function	protein complex binding	233	19034	241	21754	5.34e-07
GO:0005667	cellular_component	transcription factor complex	220	19034	227	21754	5.34e-07
GO:0010468	biological_process	regulation of gene expression	245	19034	254	21754	5.72e-07
GO:0003682	molecular_function	chromatin binding	392	19034	414	21754	6.25e-07
GO:0050821	biological_process	protein stabilization	127	19034	128	21754	6.91e-07
GO:0006897	biological_process	endocytosis	160	19034	163	21754	7.76e-07
GO:0018105	biological_process	peptidyl-serine phosphorylation	142	19034	144	21754	9.73e-07
GO:0007507	biological_process	heart development	227	19034	235	21754	9.85e-07
GO:0005509	molecular_function	calcium ion binding	643	19034	691	21754	1.00e-06
GO:0008017	molecular_function	microtubule binding	198	19034	204	21754	1.34e-06
GO:0030425	cellular_component	dendrite	328	19034	345	21754	1.45e-06

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichment/3_GO_significant.xlsx

Target gene of GO enrichment analysis:

GO ID	Transcript ID	Gene ID	Symbol	Gene_Annoation	miRNA	GO Function	GO name	Pvalue of Fisher's Exact Test
GO:0005737	ENSMUST00000148602	ENSMUSG00000000416	Cttnbp2	cortactin binding protein 2 [Source:MGI Symbol;Acc:MGI:1353467]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000088546	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114653	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114654	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114655	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114656	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114657	ENSMUSG00000000838	Fmr1	fragile X mental retardation syndrome 1 [Source:MGI Symbol;Acc:MGI:95564]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000001326	ENSMUSG00000001280	Sp1	trans-acting transcription factor 1 [Source:MGI Symbol;Acc:MGI:98372]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000163709	ENSMUSG00000001280	Sp1	trans-acting transcription factor 1 [Source:MGI Symbol;Acc:MGI:98372]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000165924	ENSMUSG00000001280	Sp1	trans-acting transcription factor 1 [Source:MGI Symbol;Acc:MGI:98372]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000215474	ENSMUSG00000001942	Siae	sialic acid acetylesterase [Source:MGI Symbol;Acc:MGI:104803]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000002292	ENSMUSG00000002222	Rmnd5a	required for meiotic nuclear division 5 homolog A [Source:MGI Symbol;Acc:MGI:1915727]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000149415	ENSMUSG00000002222	Rmnd5a	required for meiotic nuclear division 5 homolog A [Source:MGI Symbol;Acc:MGI:1915727]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000172450	ENSMUSG00000003131	Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 [Source:MGI Symbol;Acc:MGI:108415]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000003320	ENSMUSG00000003235	Eif2b5	eukaryotic translation initiation factor 2B, subunit 5 epsilon [Source:MGI Symbol;Acc:MGI:2446176]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000049567	ENSMUSG00000003308	Keap1	kelch-like ECH-associated protein 1 [Source:MGI Symbol;Acc:MGI:1858732]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000164812	ENSMUSG00000003308	Keap1	kelch-like ECH-associated protein 1 [Source:MGI Symbol;Acc:MGI:1858732]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000194542	ENSMUSG00000003308	Keap1	kelch-like ECH-associated protein 1 [Source:MGI Symbol;Acc:MGI:1858732]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000212297	ENSMUSG00000003657	Calb2	calbindin 2 [Source:MGI Symbol;Acc:MGI:101914]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000077440	ENSMUSG00000003847	Nfat5	nuclear factor of activated T cells 5 [Source:MGI Symbol;Acc:MGI:1859333]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000133026	ENSMUSG00000003847	Nfat5	nuclear factor of activated T cells 5 [Source:MGI Symbol;Acc:MGI:1859333]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000169453	ENSMUSG00000003847	Nfat5	nuclear factor of activated T cells 5 [Source:MGI Symbol;Acc:MGI:1859333]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000043812	ENSMUSG00000004591	Pkn2	protein kinase N2 [Source:MGI Symbol;Acc:MGI:109211]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000006367	ENSMUSG00000006205	Htra1	HtrA serine peptidase 1 [Source:MGI Symbol;Acc:MGI:1929076]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000113229	ENSMUSG00000006262	Mob1b	MOB kinase activator 1B [Source:MGI Symbol;Acc:MGI:1915723]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000067692	ENSMUSG00000007646	Rad51c	RAD51 paralog C [Source:MGI Symbol;Acc:MGI:2150020]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000040599	ENSMUSG00000009418	Nav1	neuron navigator 1 [Source:MGI Symbol;Acc:MGI:2183683]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000067414	ENSMUSG00000009418	Nav1	neuron navigator 1 [Source:MGI Symbol;Acc:MGI:2183683]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000190298	ENSMUSG00000009418	Nav1	neuron navigator 1 [Source:MGI Symbol;Acc:MGI:2183683]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000009972	ENSMUSG00000009828	Ick	intestinal cell kinase [Source:MGI Symbol;Acc:MGI:1934157]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000010191	ENSMUSG00000010047	Hyal2	hyaluronoglucosaminidase 2 [Source:MGI Symbol;Acc:MGI:1196334]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000195681	ENSMUSG00000010047	Hyal2	hyaluronoglucosaminidase 2 [Source:MGI Symbol;Acc:MGI:1196334]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000195752	ENSMUSG00000010047	Hyal2	hyaluronoglucosaminidase 2 [Source:MGI Symbol;Acc:MGI:1196334]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000074366	ENSMUSG00000010461	Eya4	EYA transcriptional coactivator and phosphatase 4 [Source:MGI Symbol;Acc:MGI:1337104]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000220299	ENSMUSG00000010461	Eya4	EYA transcriptional coactivator and phosphatase 4 [Source:MGI Symbol;Acc:MGI:1337104]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000010736	ENSMUSG00000010592	Dazl	deleted in azoospermia-like [Source:MGI Symbol;Acc:MGI:1342328]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000170350	ENSMUSG00000012535	Tnpo3	transportin 3 [Source:MGI Symbol;Acc:MGI:1196412]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000059849	ENSMUSG00000013465	Nelfb	negative elongation factor complex member B [Source:MGI Symbol;Acc:MGI:1931035]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000205741	ENSMUSG00000013465	Nelfb	negative elongation factor complex member B [Source:MGI Symbol;Acc:MGI:1931035]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000013842	ENSMUSG00000013698	Pea15a	phosphoprotein enriched in astrocytes 15A [Source:MGI Symbol;Acc:MGI:104799]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000111247	ENSMUSG00000013698	Pea15a	phosphoprotein enriched in astrocytes 15A [Source:MGI Symbol;Acc:MGI:104799]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000111289	ENSMUSG00000013997	Nit1	nitrilase 1 [Source:MGI Symbol;Acc:MGI:1350916]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000111295	ENSMUSG00000013997	Nit1	nitrilase 1 [Source:MGI Symbol;Acc:MGI:1350916]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000114017	ENSMUSG00000015222	Map2	microtubule-associated protein 2 [Source:MGI Symbol;Acc:MGI:97175]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000016088	ENSMUSG00000015944	Gatsl2	GATS protein-like 2 [Source:MGI Symbol;Acc:MGI:1933384]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000056177	ENSMUSG00000016664	Pacsin2	protein kinase C and casein kinase substrate in neurons 2 [Source:MGI Symbol;Acc:MGI:1345153]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000165095	ENSMUSG00000016664	Pacsin2	protein kinase C and casein kinase substrate in neurons 2 [Source:MGI Symbol;Acc:MGI:1345153]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000171436	ENSMUSG00000016664	Pacsin2	protein kinase C and casein kinase substrate in neurons 2 [Source:MGI Symbol;Acc:MGI:1345153]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000110391	ENSMUSG00000016756	Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000167746	ENSMUSG00000016756	Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000123726	ENSMUSG00000017421	Zfp207	zinc finger protein 207 [Source:MGI Symbol;Acc:MGI:1340045]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000076817	ENSMUSG00000019820	Utrn	utrophin [Source:MGI Symbol;Acc:MGI:104631]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000218635	ENSMUSG00000019820	Utrn	utrophin [Source:MGI Symbol;Acc:MGI:104631]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000219003	ENSMUSG00000019820	Utrn	utrophin [Source:MGI Symbol;Acc:MGI:104631]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000019997	ENSMUSG00000019850	Tnfaip3	tumor necrosis factor, alpha-induced protein 3 [Source:MGI Symbol;Acc:MGI:1196377]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000105527	ENSMUSG00000019850	Tnfaip3	tumor necrosis factor, alpha-induced protein 3 [Source:MGI Symbol;Acc:MGI:1196377]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020008	ENSMUSG00000019861	Gopc	golgi associated PDZ and coiled-coil motif containing [Source:MGI Symbol;Acc:MGI:2149946]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000105475	ENSMUSG00000019861	Gopc	golgi associated PDZ and coiled-coil motif containing [Source:MGI Symbol;Acc:MGI:2149946]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000217753	ENSMUSG00000019861	Gopc	golgi associated PDZ and coiled-coil motif containing [Source:MGI Symbol;Acc:MGI:2149946]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000105283	ENSMUSG00000019966	Kitl	kit ligand [Source:MGI Symbol;Acc:MGI:96974]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020208	ENSMUSG00000020021	Fgd6	FYVE, RhoGEF and PH domain containing 6 [Source:MGI Symbol;Acc:MGI:1261419]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020288	ENSMUSG00000020091	Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2 [Source:MGI Symbol;Acc:MGI:109198]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020329	ENSMUSG00000020122	Egfr	epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000220377	ENSMUSG00000020124	Usp15	ubiquitin specific peptidase 15 [Source:MGI Symbol;Acc:MGI:101857]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020349	ENSMUSG00000020135	Apc2	adenomatosis polyposis coli 2 [Source:MGI Symbol;Acc:MGI:1346052]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000105359	ENSMUSG00000020135	Apc2	adenomatosis polyposis coli 2 [Source:MGI Symbol;Acc:MGI:1346052]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000000137	ENSMUSG00000020152	Actr2	ARP2 actin-related protein 2 [Source:MGI Symbol;Acc:MGI:1913963]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020501	ENSMUSG00000020265	Sumo3	small ubiquitin-like modifier 3 [Source:MGI Symbol;Acc:MGI:1336201]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000099538	ENSMUSG00000020265	Sumo3	small ubiquitin-like modifier 3 [Source:MGI Symbol;Acc:MGI:1336201]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000124024	ENSMUSG00000020265	Sumo3	small ubiquitin-like modifier 3 [Source:MGI Symbol;Acc:MGI:1336201]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000137841	ENSMUSG00000020265	Sumo3	small ubiquitin-like modifier 3 [Source:MGI Symbol;Acc:MGI:1336201]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000102864	ENSMUSG00000020275	Rel	reticuloendotheliosis oncogene [Source:MGI Symbol;Acc:MGI:97897]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000109412	ENSMUSG00000020300	Cpeb4	cytoplasmic polyadenylation element binding protein 4 [Source:MGI Symbol;Acc:MGI:1914829]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000155278	ENSMUSG00000020300	Cpeb4	cytoplasmic polyadenylation element binding protein 4 [Source:MGI Symbol;Acc:MGI:1914829]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020551	ENSMUSG00000020305	Asb3	ankyrin repeat and SOCS box-containing 3 [Source:MGI Symbol;Acc:MGI:1929749]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000137306	ENSMUSG00000020305	Asb3	ankyrin repeat and SOCS box-containing 3 [Source:MGI Symbol;Acc:MGI:1929749]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000074669	ENSMUSG00000020358	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B [Source:MGI Symbol;Acc:MGI:1330294]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000101249	ENSMUSG00000020358	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B [Source:MGI Symbol;Acc:MGI:1330294]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000109103	ENSMUSG00000020358	Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B [Source:MGI Symbol;Acc:MGI:1330294]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000145353	ENSMUSG00000020362	Cnot6	CCR4-NOT transcription complex, subunit 6 [Source:MGI Symbol;Acc:MGI:2144529]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020634	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000102778	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000109179	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000164643	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000178543	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020755	ENSMUSG00000020463	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B [Source:MGI Symbol;Acc:MGI:2144474]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020794	ENSMUSG00000020492	Ska2	spindle and kinetochore associated complex subunit 2 [Source:MGI Symbol;Acc:MGI:1913390]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020846	ENSMUSG00000020538	Srebf1	sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000134660	ENSMUSG00000020538	Srebf1	sterol regulatory element binding transcription factor 1 [Source:MGI Symbol;Acc:MGI:107606]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000107872	ENSMUSG00000020546	Stxbp4	syntaxin binding protein 4 [Source:MGI Symbol;Acc:MGI:1342296]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000107875	ENSMUSG00000020546	Stxbp4	syntaxin binding protein 4 [Source:MGI Symbol;Acc:MGI:1342296]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000020886	ENSMUSG00000020572	Nampt	nicotinamide phosphoribosyltransferase [Source:MGI Symbol;Acc:MGI:1929865]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000092915	ENSMUSG00000020741	Cluh	clustered mitochondria (cluA/CLU1) homolog [Source:MGI Symbol;Acc:MGI:1921398]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000117818	ENSMUSG00000020741	Cluh	clustered mitochondria (cluA/CLU1) homolog [Source:MGI Symbol;Acc:MGI:1921398]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000155998	ENSMUSG00000020790	Ankfy1	ankyrin repeat and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:1337008]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000076270	ENSMUSG00000020817	Rabep1	rabaptin, RAB GTPase binding effector protein 1 [Source:MGI Symbol;Acc:MGI:1860236]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000021282	ENSMUSG00000020899	Pfas	phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) [Source:MGI Symbol;Acc:MGI:2684864]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000021416	ENSMUSG00000021028	Mbip	MAP3K12 binding inhibitory protein 1 [Source:MGI Symbol;Acc:MGI:1918320]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94
GO:0005737	ENSMUST00000110464	ENSMUSG00000021109	Hif1a	hypoxia inducible factor 1, alpha subunit [Source:MGI Symbol;Acc:MGI:106918]	mmu-miR-24-2-5p	cellular_component	cytoplasm	2.94e-94

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichment/3_GO_miRNA_Gene.xlsx

Barplot of enriched GO terms:

document location: Final_Report/Target_Enrichment_Analysis/GO_Pictures/GO_bar_graph.png

Scatterplot of enriched GO terms:

Number of target genes enriched in GO terms, p value and rich factor are shown in scatterplot. Rich factor=(number of target genes in GO term)/(total number of genes in GO term). The larger rich factor is, the higher enrichment is.

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichments/GO_enrichment_scatterplot.pdf

5.3 KEGG enrichment analysis of target genes

KEGG (Kyoto Encyclopedia of Genes and Genomes) (http://www.kegg.jp/) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances. KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.

Significant KEGG pathways were calculated by Hypergeometric equation as shown below. TB gene number=number of total genes; TS gene number=number of target genes in total genes; B gene number=total number of genes in KEGG pathways; S gene number=number of target genes in this KEGG pathway. Those KEGG pathways with p value<0.05 were defined as significant KEGG pathways.

Significant KEGG pathways:

Pathway Id	Pathway description	S gene number	TS gene number	B gene number	TB gene number	Pvalue of Fisher's Exact Test
ko04310	Wnt signaling pathway	141	6841	141	7580	4.53e-07
ko04360	Axon guidance	129	6841	129	7580	1.58e-06
ko05200	Pathways in cancer	378	6841	392	7580	1.74e-06
ko04550	Signaling pathways regulating pluripotency of stem cells	139	6841	140	7580	8.27e-06
ko04010	MAPK signaling pathway	246	6841	253	7580	1.16e-05
ko04144	Endocytosis	222	6841	228	7580	2.15e-05
ko04142	Lysosome	122	6841	123	7580	4.32e-05
ko04014	Ras signaling pathway	221	6841	228	7580	7.98e-05
ko04120	Ubiquitin mediated proteolysis	135	6841	137	7580	8.89e-05
ko04390	Hippo signaling pathway	150	6841	153	7580	0.00
ko05169	Epstein-Barr virus infection	197	6841	203	7580	0.00
ko04141	Protein processing in endoplasmic reticulum	162	6841	166	7580	0.00
ko04152	AMPK signaling pathway	125	6841	127	7580	0.00
ko05166	HTLV-I infection	261	6841	272	7580	0.00
ko04071	Sphingolipid signaling pathway	120	6841	122	7580	0.00
ko04510	Focal adhesion	200	6841	207	7580	0.00
ko05205	Proteoglycans in cancer	198	6841	205	7580	0.00
ko04919	Thyroid hormone signaling pathway	116	6841	118	7580	0.00
ko04068	FoxO signaling pathway	132	6841	135	7580	0.00
ko04668	TNF signaling pathway	106	6841	108	7580	0.00
ko00562	Inositol phosphate metabolism	63	6841	63	7580	0.00
ko04721	Synaptic vesicle cycle	62	6841	62	7580	0.00
ko04015	Rap1 signaling pathway	205	6841	214	7580	0.00
ko04024	cAMP signaling pathway	190	6841	198	7580	0.00
ko04070	Phosphatidylinositol signaling system	81	6841	82	7580	0.00
ko05231	Choline metabolism in cancer	99	6841	101	7580	0.00
ko05323	Rheumatoid arthritis	80	6841	81	7580	0.00
ko04916	Melanogenesis	98	6841	100	7580	0.00
ko00330	Arginine and proline metabolism	58	6841	58	7580	0.00
ko04728	Dopaminergic synapse	126	6841	130	7580	0.00
ko05217	Basal cell carcinoma	55	6841	55	7580	0.00
ko05145	Toxoplasmosis	109	6841	112	7580	0.00
ko04114	Oocyte meiosis	109	6841	112	7580	0.00
ko04910	Insulin signaling pathway	136	6841	141	7580	0.00
ko04110	Cell cycle	120	6841	124	7580	0.01
ko04920	Adipocytokine signaling pathway	71	6841	72	7580	0.01
ko04722	Neurotrophin signaling pathway	118	6841	122	7580	0.01
ko04660	T cell receptor signaling pathway	102	6841	105	7580	0.01
ko04330	Notch signaling pathway	49	6841	49	7580	0.01
ko04340	Hedgehog signaling pathway	49	6841	49	7580	0.01
ko04012	ErbB signaling pathway	85	6841	87	7580	0.01
ko04666	Fc gamma R-mediated phagocytosis	84	6841	86	7580	0.01
ko05031	Amphetamine addiction	66	6841	67	7580	0.01
ko05222	Small cell lung cancer	82	6841	84	7580	0.01
ko05212	Pancreatic cancer	65	6841	66	7580	0.01
ko04611	Platelet activation	125	6841	130	7580	0.01
ko05214	Glioma	64	6841	65	7580	0.01
ko04921	Oxytocin signaling pathway	151	6841	158	7580	0.01
ko04724	Glutamatergic synapse	110	6841	114	7580	0.01
ko04146	Peroxisome	80	6841	82	7580	0.01
ko04350	TGF-beta signaling pathway	79	6841	81	7580	0.01
ko03018	RNA degradation	78	6841	80	7580	0.01
ko04020	Calcium signaling pathway	172	6841	181	7580	0.01
ko05100	Bacterial invasion of epithelial cells	76	6841	78	7580	0.01
ko05132	Salmonella infection	76	6841	78	7580	0.01
ko00564	Glycerophospholipid metabolism	91	6841	94	7580	0.01
ko04380	Osteoclast differentiation	119	6841	124	7580	0.01
ko01230	Biosynthesis of amino acids	75	6841	77	7580	0.02
ko05033	Nicotine addiction	40	6841	40	7580	0.02
ko04612	Antigen processing and presentation	74	6841	76	7580	0.02
ko04810	Regulation of actin cytoskeleton	204	6841	216	7580	0.02
ko05321	Inflammatiory bowel disease (IBD)	57	6841	58	7580	0.02
ko04520	Adherens junction	72	6841	74	7580	0.02
ko05221	Acute myeloid leukemia	56	6841	57	7580	0.02
ko04621	NOD-like receptor signaling pathway	56	6841	57	7580	0.02
ko05220	Chronic myeloid leukemia	71	6841	73	7580	0.02
ko04512	ECM-receptor interaction	85	6841	88	7580	0.02
ko04662	B cell receptor signaling pathway	70	6841	72	7580	0.02
ko00240	Pyrimidine metabolism	98	6841	102	7580	0.02
ko04723	Retrograde endocannabinoid signaling	98	6841	102	7580	0.02
ko00500	Starch and sucrose metabolism	53	6841	54	7580	0.03
ko05340	Primary immunodeficiency	35	6841	35	7580	0.03
ko05144	Malaria	52	6841	53	7580	0.03
ko05213	Endometrial cancer	51	6841	52	7580	0.03
ko04915	Estrogen signaling pathway	94	6841	98	7580	0.03
ko04115	p53 signaling pathway	66	6841	68	7580	0.03
ko03460	Fanconi anemia pathway	50	6841	51	7580	0.03
ko00410	beta-Alanine metabolism	32	6841	32	7580	0.04
ko05211	Renal cell carcinoma	64	6841	66	7580	0.04
ko00010	Glycolysis / Gluconeogenesis	64	6841	66	7580	0.04
ko04720	Long-term potentiation	64	6841	66	7580	0.04
ko01200	Carbon metabolism	103	6841	108	7580	0.04
ko00510	N-Glycan biosynthesis	48	6841	49	7580	0.04
ko05030	Cocaine addiction	48	6841	49	7580	0.04
ko00514	Other types of O-glycan biosynthesis	31	6841	31	7580	0.04
ko05210	Colorectal cancer	62	6841	64	7580	0.04
ko04710	Circadian rhythm	30	6841	30	7580	0.05
ko05032	Morphine addiction	88	6841	92	7580	0.05
ko04150	mTOR signaling pathway	59	6841	61	7580	0.05
ko00512	Mucin type O-glycan biosynthesis	28	6841	28	7580	0.06
ko04912	GnRH signaling pathway	85	6841	89	7580	0.06
ko05215	Prostate cancer	85	6841	89	7580	0.06
ko04514	Cell adhesion molecules (CAMs)	145	6841	154	7580	0.06
ko04370	VEGF signaling pathway	58	6841	60	7580	0.06
ko04730	Long-term depression	58	6841	60	7580	0.06
ko04727	GABAergic synapse	84	6841	88	7580	0.06
ko04971	Gastric acid secretion	71	6841	74	7580	0.06
ko04917	Prolactin signaling pathway	71	6841	74	7580	0.06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	71	6841	74	7580	0.06

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichment/4_KEGG_significant.xlsx

Target gene of KEGG enrichment analysis:

KEGG ID	Transcript ID	Gene ID	Symbol	Gene Annoation	miRNA	KEGG Name	Pvalue of Fisher's Exact Test
ko04310	ENSMUST00000020349	ENSMUSG00000020135	Apc2	adenomatosis polyposis coli 2 [Source:MGI Symbol;Acc:MGI:1346052]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000105359	ENSMUSG00000020135	Apc2	adenomatosis polyposis coli 2 [Source:MGI Symbol;Acc:MGI:1346052]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000020634	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000102778	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109179	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000164643	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000178543	ENSMUSG00000020366	Mapk9	mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000020904	ENSMUSG00000020580	Rock2	Rho-associated coiled-coil containing protein kinase 2 [Source:MGI Symbol;Acc:MGI:107926]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000022504	ENSMUSG00000021936	Mapk8	mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000111945	ENSMUSG00000021936	Mapk8	mitogen-activated protein kinase 8 [Source:MGI Symbol;Acc:MGI:1346861]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000025075	ENSMUSG00000024232	Bambi	BMP and activin membrane-bound inhibitor [Source:MGI Symbol;Acc:MGI:1915260]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000041163	ENSMUSG00000036961	Wnt8b	wingless-type MMTV integration site family, member 8B [Source:MGI Symbol;Acc:MGI:109485]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000086854	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112846	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112847	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112848	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000170792	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-24-2-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000133689	ENSMUSG00000006932	Ctnnb1	catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000154356	ENSMUSG00000006932	Ctnnb1	catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000163844	ENSMUSG00000006932	Ctnnb1	catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000007959	ENSMUSG00000007815	Rhoa	ras homolog family member A [Source:MGI Symbol;Acc:MGI:1096342]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000071816	ENSMUSG00000021820	Camk2g	calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000080440	ENSMUSG00000021820	Camk2g	calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000100837	ENSMUSG00000021820	Camk2g	calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000063465	ENSMUSG00000021994	Wnt5a	wingless-type MMTV integration site family, member 5A [Source:MGI Symbol;Acc:MGI:98958]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112272	ENSMUSG00000021994	Wnt5a	wingless-type MMTV integration site family, member 5A [Source:MGI Symbol;Acc:MGI:98958]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000030839	ENSMUSG00000028988	Ctnnbip1	catenin beta interacting protein 1 [Source:MGI Symbol;Acc:MGI:1915756]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109308	ENSMUSG00000031902	Nfatc3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [Source:MGI Symbol;Acc:MGI:103296]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000211991	ENSMUSG00000031902	Nfatc3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [Source:MGI Symbol;Acc:MGI:103296]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000043214	ENSMUSG00000033220	Rac2	RAS-related C3 botulinum substrate 2 [Source:MGI Symbol;Acc:MGI:97846]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000006716	ENSMUSG00000033227	Wnt6	wingless-type MMTV integration site family, member 6 [Source:MGI Symbol;Acc:MGI:98960]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000054294	ENSMUSG00000044674	Fzd1	frizzled class receptor 1 [Source:MGI Symbol;Acc:MGI:1196625]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000089752	ENSMUSG00000053754	Chd8	chromodomain helicase DNA binding protein 8 [Source:MGI Symbol;Acc:MGI:1915022]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000149975	ENSMUSG00000053754	Chd8	chromodomain helicase DNA binding protein 8 [Source:MGI Symbol;Acc:MGI:1915022]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000200169	ENSMUSG00000053754	Chd8	chromodomain helicase DNA binding protein 8 [Source:MGI Symbol;Acc:MGI:1915022]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000099224	ENSMUSG00000074698	Csnk2a1	casein kinase 2, alpha 1 polypeptide [Source:MGI Symbol;Acc:MGI:88543]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000203081	ENSMUSG00000078816	Prkcg	protein kinase C, gamma [Source:MGI Symbol;Acc:MGI:97597]	mmu-miR-8114	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000080537	ENSMUSG00000001847	Rac1	RAS-related C3 botulinum substrate 1 [Source:MGI Symbol;Acc:MGI:97845]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000100489	ENSMUSG00000001847	Rac1	RAS-related C3 botulinum substrate 1 [Source:MGI Symbol;Acc:MGI:97845]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000022971	ENSMUSG00000022346	Myc	myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000159327	ENSMUSG00000022346	Myc	myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000160009	ENSMUSG00000022346	Myc	myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000161976	ENSMUSG00000022346	Myc	myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000167731	ENSMUSG00000022346	Myc	myelocytomatosis oncogene [Source:MGI Symbol;Acc:MGI:97250]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000023015	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109424	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000167968	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-451a_R+1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000080537	ENSMUSG00000001847	Rac1	RAS-related C3 botulinum substrate 1 [Source:MGI Symbol;Acc:MGI:97845]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000010941	ENSMUSG00000010797	Wnt2	wingless-type MMTV integration site family, member 2 [Source:MGI Symbol;Acc:MGI:98954]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000142739	ENSMUSG00000017376	Nlk	nemo like kinase [Source:MGI Symbol;Acc:MGI:1201387]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000018630	ENSMUSG00000018486	Wnt9b	wingless-type MMTV integration site family, member 9B [Source:MGI Symbol;Acc:MGI:1197020]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000022906	ENSMUSG00000022297	Fzd6	frizzled class receptor 6 [Source:MGI Symbol;Acc:MGI:108474]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000179165	ENSMUSG00000022297	Fzd6	frizzled class receptor 6 [Source:MGI Symbol;Acc:MGI:108474]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000023015	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109424	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000167968	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000023507	ENSMUSG00000022812	Gsk3b	glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000114750	ENSMUSG00000022812	Gsk3b	glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000172271	ENSMUSG00000023411	Nfatc4	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 [Source:MGI Symbol;Acc:MGI:1920431]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000025075	ENSMUSG00000024232	Bambi	BMP and activin membrane-bound inhibitor [Source:MGI Symbol;Acc:MGI:1915260]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000176867	ENSMUSG00000024913	Lrp5	low density lipoprotein receptor-related protein 5 [Source:MGI Symbol;Acc:MGI:1278315]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000065601	ENSMUSG00000025217	Btrc	beta-transducin repeat containing protein [Source:MGI Symbol;Acc:MGI:1338871]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000111936	ENSMUSG00000025217	Btrc	beta-transducin repeat containing protein [Source:MGI Symbol;Acc:MGI:1338871]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000037607	ENSMUSG00000028284	Map3k7	mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000080933	ENSMUSG00000028284	Map3k7	mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000108183	ENSMUSG00000028284	Map3k7	mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000108184	ENSMUSG00000028284	Map3k7	mitogen-activated protein kinase kinase kinase 7 [Source:MGI Symbol;Acc:MGI:1346877]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000030839	ENSMUSG00000028988	Ctnnbip1	catenin beta interacting protein 1 [Source:MGI Symbol;Acc:MGI:1915756]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000032180	ENSMUSG00000030093	Wnt7a	wingless-type MMTV integration site family, member 7A [Source:MGI Symbol;Acc:MGI:98961]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000034086	ENSMUSG00000031661	Nkd1	naked cuticle 1 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:2135954]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000034973	ENSMUSG00000032402	Smad3	SMAD family member 3 [Source:MGI Symbol;Acc:MGI:1201674]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000078049	ENSMUSG00000033016	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [Source:MGI Symbol;Acc:MGI:102469]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000167977	ENSMUSG00000033016	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [Source:MGI Symbol;Acc:MGI:102469]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000170905	ENSMUSG00000033016	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [Source:MGI Symbol;Acc:MGI:102469]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000041163	ENSMUSG00000036961	Wnt8b	wingless-type MMTV integration site family, member 8B [Source:MGI Symbol;Acc:MGI:109485]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000063982	ENSMUSG00000045005	Fzd5	frizzled class receptor 5 [Source:MGI Symbol;Acc:MGI:108571]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000056919	ENSMUSG00000046707	Csnk2a2	casein kinase 2, alpha prime polypeptide [Source:MGI Symbol;Acc:MGI:88547]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000086854	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112847	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000112848	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000170792	ENSMUSG00000046709	Mapk10	mitogen-activated protein kinase 10 [Source:MGI Symbol;Acc:MGI:1346863]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000058755	ENSMUSG00000049791	Fzd4	frizzled class receptor 4 [Source:MGI Symbol;Acc:MGI:108520]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000059595	ENSMUSG00000050965	Prkca	protein kinase C, alpha [Source:MGI Symbol;Acc:MGI:97595]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000099224	ENSMUSG00000074698	Csnk2a1	casein kinase 2, alpha 1 polypeptide [Source:MGI Symbol;Acc:MGI:88543]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000117102	ENSMUSG00000081683	Fzd10	frizzled class receptor 10 [Source:MGI Symbol;Acc:MGI:2136761]	mmu-miR-199a-5p	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000000127	ENSMUSG00000000125	Wnt3	wingless-type MMTV integration site family, member 3 [Source:MGI Symbol;Acc:MGI:98955]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000086844	ENSMUSG00000000782	Tcf7	transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109071	ENSMUSG00000000782	Tcf7	transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000005606	ENSMUSG00000005469	Prkaca	protein kinase, cAMP dependent, catalytic, alpha [Source:MGI Symbol;Acc:MGI:97592]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000165590	ENSMUSG00000005871	Apc	adenomatosis polyposis coli [Source:MGI Symbol;Acc:MGI:88039]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000154356	ENSMUSG00000006932	Ctnnb1	catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000163844	ENSMUSG00000006932	Ctnnb1	catenin (cadherin associated protein), beta 1 [Source:MGI Symbol;Acc:MGI:88276]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000165240	ENSMUSG00000015957	Wnt11	wingless-type MMTV integration site family, member 11 [Source:MGI Symbol;Acc:MGI:101948]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000018966	ENSMUSG00000018822	Sfrp5	secreted frizzled-related sequence protein 5 [Source:MGI Symbol;Acc:MGI:1860298]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000022051	ENSMUSG00000021567	Nkd2	naked cuticle 2 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1919543]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000118096	ENSMUSG00000021567	Nkd2	naked cuticle 2 homolog (Drosophila) [Source:MGI Symbol;Acc:MGI:1919543]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000023015	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000109424	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07
ko04310	ENSMUST00000167968	ENSMUSG00000022382	Wnt7b	wingless-type MMTV integration site family, member 7B [Source:MGI Symbol;Acc:MGI:98962]	mmu-miR-1968-5p_R-1	Wnt signaling pathway	4.53e-07

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichment/4_KEGG_miRNA_Gene.xlsx

Scatterplot of enriched KEGG pathways:

Number of target genes enriched in KEGG pathway, p value and rich factor are shown in scatterplot. Rich factor=(number of target genes in KEGG pathway)/(total number of genes in KEGG pathway). The larger rich factor is, the higher enrichment is.

document location: Final_Report/Target_Enrichment_Analysis/Target_Enrichments/KEGG_enrichment_scatterplot.pdf

KEGG pathway maps:

Graphical map objects

The KEGG pathway map is a moleculalr interaction/reaction network diagram represented in terms of the KEGG Orthology (KO) groups, so that experimental evidence in specific organisms can be generalized to other organisms through genomic information. Each map is manually drawn with in-house software called KegSketch, which generates the KGML+ file. This file is an SVG file containing graphics objects that are associated with KEGG objects (see KEGG object identifiers). Basic graphics objects in the reference KEGG pathway maps are:

boxes - ortholog (KO) groups identified by K numbers and, in metabolic maps, reactions identified by R numbers as well

circles - other molecules, usually chemical compounds identified by C numbers, but including glycans identified by G numbers

lines - reactions identified by R numbers in metabolic maps; ortholog (KO) groups identified by K numbers in global metabolism maps

and in organism specific pathway maps that are computationally generated:

boxes - genes or gene products identified by the combination of the KEGG organism code and gene identifiers

These map objects can be searched in the search box at the top of the KEGG PATHWAY page, in the search box in each pathway map, and by the KEGG Mapper tools.

Convention of map number prefix

Each pathway map is identified by the combination of 2-4 letter code and 5 digit number (see KEGG Identifiers). The prefix has the following meaning:

map - Reference pathway

ko - Reference pathway (KO)

ec - Reference pathway (EC)

rn - Reference pathway (Reaction)

org - Organism-specific pathway map

Only the first reference pathway map is manually drawn; all other maps are computationally generated. For metabolic pathways, each box (or line) in the reference map is linked to the K number (KO identifeir), the EC number, and the R number (reaction identifier). The KO, EC, and reaction maps are linked to only one of them. For all metabolic and non-metabolic maps, K numbers are converted to gene identifiers in each organism to generate organism-specific pathways.

As shown above, "map" pathways are not colored, "ko/ec/rn" pathways are colored blue, and organism-specific pathways are colored green, where coloring indicates that map objects exist and are linked to corresponding entries. For global metabolism maps, "map" pathways are fully colored, so that "ko/ec/rn" pathways and organism-specific pathways are generated by reducing the coloring indicating the absence of corresponding entries.

In this study, all KEGG pathway maps were deposited in Final_Report/Target_Enrichment_Analysis/KEGG_Pictures/.

5.4 Network between miRNAs and target genes

Cytoscape is an open source software platform for visualizing molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data. Node files and edge files (Core elements in cytoscape) are deposited in /Final_Report /Target_Enrichment_Analysis /Network_Result /Node_info/ and Final_Report /Target_Enrichment_Analysis /Network_Result /Network. After opening Cytoscape software, you could click File->Import->Network->File to load edge files and File->Import->Style to load node files. For more details, please browse http://manual.cytoscape.org/en/stable/index.html or download manual from Cytoscape3_6_0Manual/pdf.

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6. References

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[13] Dai X, Zhao PX. psRNATarget: a plant small RNA target analysis server. Nucleic Acids Res., 2011, 39(suppl 2): W155-W159.

[14] Franceschini, A., et al. Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. PNAS, 2014, 111(12), 4548-4553.

[15] Zhou, L., Canagarajah, B., Zhao, Y., Baibakov, B., Tokuhiro, K., Maric, D., & Dean, J. BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice. Developmental Cell, 2017, 40(5), 453-466.

[16] Han, X., et al. Integration of small RNAs, degradome and transcriptome sequencing in hyperaccumulator Sedum alfredii uncovers a complex regulatory network and provides insights into cadmium phytoremediation. Plant Biotech. J., 2015, 14(6), 1470-1483

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